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Secretin-stimulated ultrasound estimation of pancreatic secretion in cystic fibrosis validated by magnetic resonance imaging.
- Source :
-
European radiology [Eur Radiol] 2018 Apr; Vol. 28 (4), pp. 1495-1503. Date of Electronic Publication: 2017 Nov 13. - Publication Year :
- 2018
-
Abstract
- Objectives: Secretin-stimulated magnetic resonance imaging (s-MRI) is the best validated radiological modality assessing pancreatic secretion. The purpose of this study was to compare volume output measures from secretin-stimulated transabdominal ultrasonography (s-US) to s-MRI for the diagnosis of exocrine pancreatic failure in cystic fibrosis (CF).<br />Methods: We performed transabdominal ultrasonography and MRI before and at timed intervals during 15 minutes after secretin stimulation in 21 CF patients and 13 healthy controls. To clearly identify the subjects with reduced exocrine pancreatic function, we classified CF patients as pancreas-sufficient or -insufficient by secretin-stimulated endoscopic short test and faecal elastase.<br />Results: Pancreas-insufficient CF patients had reduced pancreatic secretions compared to pancreas-sufficient subjects based on both imaging modalities (p < 0.001). Volume output estimates assessed by s-US correlated to that of s-MRI (r = 0.56-0.62; p < 0.001). Both s-US (AUC: 0.88) and s-MRI (AUC: 0.99) demonstrated good diagnostic accuracy for exocrine pancreatic failure.<br />Conclusions: Pancreatic volume-output estimated by s-US corresponds well to exocrine pancreatic function in CF patients and yields comparable results to that of s-MRI. s-US provides a simple and feasible tool in the assessment of pancreatic secretion.<br />Key Points: • Cystic fibrosis patients with affected pancreas have reduced pancreatic secretions. • Secretin-stimulated sonography is a simple and feasible method to assess pancreatic output. • Secretin-simulated MRI is a more precise method to assess pancreatic secretions. • The sonographic and MRI methods yielded comparable pancreatic secretory output estimates.
- Subjects :
- Adult
Cystic Fibrosis complications
Cystic Fibrosis metabolism
Endoscopy
Exocrine Pancreatic Insufficiency diagnosis
Exocrine Pancreatic Insufficiency etiology
Female
Humans
Male
Pancreas, Exocrine metabolism
Cystic Fibrosis diagnosis
Exocrine Pancreatic Insufficiency metabolism
Magnetic Resonance Imaging methods
Pancreas, Exocrine diagnostic imaging
Pancreatic Juice metabolism
Secretin metabolism
Ultrasonography methods
Subjects
Details
- Language :
- English
- ISSN :
- 1432-1084
- Volume :
- 28
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- European radiology
- Publication Type :
- Academic Journal
- Accession number :
- 29134356
- Full Text :
- https://doi.org/10.1007/s00330-017-5115-2