Drug Repositioning Meets Precision in Glioblastoma.

Authors :: Wick W
Kessler T
Source :: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2018 Jan 15; Vol. 24 (2), pp. 256-258. Date of Electronic Publication: 2017 Nov 13.
Publication Year :: 2018
Abstract: Glioblastoma has a gigantic unmet medical need. Molecular knowledge has evolved substantially, including data on clonal selection with progression. Past trials for all-comers may have produced false negative results. Molecular precision at progression needs workup of new tissue, and revisiting drugs with a focus on brain tumor penetration may yield surprises. Clin Cancer Res; 24(2); 256-8. ©2017 AACR See related article by Byron et al., p. 295 .<br /> (©2017 American Association for Cancer Research.)

Subjects :: Adult
Drug Repositioning
Genomics
Humans
Prospective Studies
Brain Neoplasms
Glioblastoma

Language :: English
ISSN :: 1557-3265
Volume :: 24
Issue :: 2
Database :: MEDLINE
Journal :: Clinical cancer research : an official journal of the American Association for Cancer Research
Publication Type :: Academic Journal
Accession number :: 29133572
Full Text :: https://doi.org/10.1158/1078-0432.CCR-17-2989