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Staphylococcus aureus Epicutaneous Exposure Drives Skin Inflammation via IL-36-Mediated T Cell Responses.
- Source :
-
Cell host & microbe [Cell Host Microbe] 2017 Nov 08; Vol. 22 (5), pp. 653-666.e5. - Publication Year :
- 2017
-
Abstract
- Staphylococcus aureus colonization contributes to skin inflammation in diseases such as atopic dermatitis, but the signaling pathways involved are unclear. Herein, epicutaneous S. aureus exposure to mouse skin promoted MyD88-dependent skin inflammation initiated by IL-36, but not IL-1α/β, IL-18, or IL-33. By contrast, an intradermal S. aureus challenge promoted MyD88-dependent host defense initiated by IL-1β rather than IL-36, suggesting that different IL-1 cytokines trigger MyD88 signaling depending on the anatomical depth of S. aureus cutaneous exposure. The bacterial virulence factor PSMα, but not α-toxin or δ-toxin, contributed to the skin inflammation, which was driven by IL-17-producing γδ and CD4 <superscript>+</superscript> T cells via direct IL-36R signaling in the T cells. Finally, adoptive transfer of IL-36R-expressing T cells to IL-36R-deficient mice was sufficient for mediating S. aureus-induced skin inflammation. Together, this study defines a previously unknown pathway by which S. aureus epicutaneous exposure promotes skin inflammation involving IL-36R/MyD88-dependent IL-17 T cell responses.<br /> (Copyright © 2017 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Bacterial Toxins immunology
CD4-Positive T-Lymphocytes immunology
Cytokines metabolism
Dermatitis, Atopic microbiology
Dermatitis, Atopic pathology
Disease Models, Animal
Female
Hemolysin Proteins immunology
Host-Parasite Interactions immunology
Inflammation pathology
Interleukin-17
Interleukin-18 metabolism
Interleukin-1alpha metabolism
Interleukin-1beta metabolism
Interleukin-33 metabolism
Male
Mice
Mice, Inbred BALB C
Myeloid Differentiation Factor 88 metabolism
Receptors, Interleukin-1 metabolism
Skin microbiology
Skin pathology
Staphylococcal Infections pathology
T-Lymphocytes microbiology
Virulence Factors immunology
Dermatitis, Atopic immunology
Inflammation immunology
Interleukin-1 immunology
Skin immunology
Staphylococcal Infections immunology
Staphylococcus aureus pathogenicity
T-Lymphocytes immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1934-6069
- Volume :
- 22
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Cell host & microbe
- Publication Type :
- Academic Journal
- Accession number :
- 29120743
- Full Text :
- https://doi.org/10.1016/j.chom.2017.10.006