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Effects of omega-3 polyunsaturated fatty acids and aspirin, alone and combined, on canine platelet function.
- Source :
-
The Journal of small animal practice [J Small Anim Pract] 2018 May; Vol. 59 (5), pp. 272-280. Date of Electronic Publication: 2017 Nov 09. - Publication Year :
- 2018
-
Abstract
- Objectives: To compare haemostatic function in healthy dogs after treatment with low-dose aspirin alone, fish oil alone or a combination of these two therapies.<br />Materials and Methods: Double-blinded randomised controlled clinical trial on 16 healthy client-owned dogs. Comprehensive haemostatic testing was performed at baseline and after 7 days of therapy with low-dose aspirin in all dogs. Following a 14-day washout, six dogs received fish oil, and nine dogs received combination therapy of aspirin plus fish oil; haemostatic testing was performed before and at 7 and 28 days after treatment initiation.<br />Results: Aspirin was associated with significantly decreased platelet function as measured by a collagen-epinephrine cartridge and inhibited arachidonic acid-induced whole-blood platelet aggregometry. Fish oil alone did not significantly affect any haemostatic tests. The combination of aspirin plus fish oil therapy caused a significantly greater inhibition of adenosine diphosphate and collagen-induced whole blood aggregometry compared to aspirin alone.<br />Clinical Significance: Fish oil added to aspirin therapy appears to augment inhibition of some measures of platelet function in healthy dogs.<br /> (© 2017 British Small Animal Veterinary Association.)
Details
- Language :
- English
- ISSN :
- 1748-5827
- Volume :
- 59
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The Journal of small animal practice
- Publication Type :
- Academic Journal
- Accession number :
- 29120035
- Full Text :
- https://doi.org/10.1111/jsap.12776