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Association of Leukotrichia in Vitiligo and Asp148Glu Polymorphism of Apurinic/Apyrimidinic Endonuclease 1.
- Source :
-
International journal of trichology [Int J Trichology] 2017 Oct-Dec; Vol. 9 (4), pp. 171-176. - Publication Year :
- 2017
-
Abstract
- Background: Oxidative stress and increased DNA damage have been implicated in the etiopathogenesis of vitiligo. Oxidative DNA damage is mainly repaired by the base excision repair (BER) pathway.<br />Aim: We sought to determine whether polymorphisms in DNA repair genes may have a role in the pathogenesis of vitiligo.<br />Materials and Methods: We conducted a study including 100 patients with vitiligo and age- and sex-matched 193 control subjects to examine the role of single-nucleotide polymorphisms of BER genes, human 8-oxoG DNA N-glycosylase 1 (codon 326), apurinic/apyrimidinic endonuclease 1 (APE1) (codon 148), and X-ray repair cross-complementing group 1 (codon 399) as risk factors for vitiligo. These polymorphisms were determined by quantitative real-time polymerase chain reaction and melting curve analysis.<br />Results: No significant association was observed between the variant alleles of studied genes and vitiligo.<br />Conclusion: However, we showed that the presence of APE1 148Glu variant allele is associated with leukotrichia. This preliminary study suggests that APE1 (codon 148) polymorphism may play a role in vitiligo pathogenesis.<br />Competing Interests: There are no conflicts of interest.
Details
- Language :
- English
- ISSN :
- 0974-7753
- Volume :
- 9
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- International journal of trichology
- Publication Type :
- Academic Journal
- Accession number :
- 29118522
- Full Text :
- https://doi.org/10.4103/ijt.ijt_4_17