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Sterilization effects on ultrathin film polymer coatings for silicon-based implantable medical devices.
- Source :
-
Journal of biomedical materials research. Part B, Applied biomaterials [J Biomed Mater Res B Appl Biomater] 2018 Aug; Vol. 106 (6), pp. 2327-2336. Date of Electronic Publication: 2017 Nov 06. - Publication Year :
- 2018
-
Abstract
- Novel biomaterials for medical device applications must be stable throughout all stages of preparation for surgery, including sterilization. There is a paucity of information on the effects of sterilization on sub-10 nm-thick polymeric surface coatings suitable for silicon-based bioartificial organs. This study explores the effect of five standard sterilization methods on three surface coatings applied to silicon: polyethylene glycol (PEG), poly(sulfobetaine methacrylate) (pSBMA), and poly (2-methacryloyloxyethyl phosphorylcholine) (pMPC). Autoclave, dry heat, hydrogen peroxide (H <subscript>2</subscript> O <subscript>2</subscript> ) plasma, ethylene oxide gas (EtO), and electron beam (E-beam) treated coatings were analyzed to determine possible polymer degradation with sterilization. Poststerilization, there were significant alterations in contact angle, maximum change resulting from H <subscript>2</subscript> O <subscript>2</subscript> (Δ - 14°), autoclave (Δ + 15°), and dry heat (Δ + 23°) treatments for PEG, pSBMA, and pMPC, respectively. Less than 5% coating thickness change was found with autoclave and EtO on PEG-silicon, E-beam on pSBMA-silicon and EtO treatment on pMPC-silicon. H <subscript>2</subscript> O <subscript>2</subscript> treatment resulted in at least 30% decrease in thickness for all coatings. Enzyme-linked immunosorbent assays showed significant protein adsorption increase for pMPC-silicon following all sterilization methods. E-beam on PEG-silicon and dry-heat treatment on pSBMA-silicon exhibited maximum protein adsorption in each coating subset. Overall, the data suggest autoclave and EtO treatments are well-suited for PEG-silicon, while E-beam is best suited for pSBMA-silicon. pMPC-silicon was least impacted by EtO treatment. H <subscript>2</subscript> O <subscript>2</subscript> treatment had a negative effect on all three coatings. These results can be used to determine which surface modifications and sterilization processes to utilize for devices in vivo. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2327-2336, 2018.<br /> (© 2017 Wiley Periodicals, Inc.)
Details
- Language :
- English
- ISSN :
- 1552-4981
- Volume :
- 106
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of biomedical materials research. Part B, Applied biomaterials
- Publication Type :
- Academic Journal
- Accession number :
- 29105972
- Full Text :
- https://doi.org/10.1002/jbm.b.34039