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Effect of Preoperative Bacteriuria and Pyuria on Intravesical Recurrence in Patients with Upper Tract Urothelial Carcinoma Undergoing Radical Nephroureterectomy.
- Source :
-
In vivo (Athens, Greece) [In Vivo] 2017 Nov-Dec; Vol. 31 (6), pp. 1215-1220. - Publication Year :
- 2017
-
Abstract
- Background/aim: We investigated the effect of bacteriuria and pyuria on intravesical recurrence (IVR) in patients with upper tract urothelial carcinoma (UTUC) undergoing radical nephroureterectomy (RNU).<br />Patients and Methods: Preoperative bacteriuria and pyuria were defined as urine containing ≥5 bacteria/high-power field (HPF) and >5 white blood cells/HPF, respectively. Their associations with IVR were evaluated in 97 patients with UTUC undergoing RNU.<br />Results: Preoperative bacteriuria [n=15 (15%)] was significantly associated with preoperative pyuria [n=42 (43%), p<0.001]. During follow-up (median of 19 months), 45 (46%) patients developed IVR (median IVR-free survival=38 months). On multivariate analysis, preoperative bacteriuria was an independent predictor for reduced risk of IVR (hazard ratio=0.23, p=0.010). The 2-year IVR-free survival of patients with preoperative bacteriuria and pyuria was significantly longer than that of patients without preoperative bacteriuria (83% vs. 54%, p=0.028) and pyuria (69% vs. 50%, p=0.024), respectively.<br />Conclusion: Bacteriuria and pyuria may reduce the risk of IVR in patients with UTUC undergoing RNU.<br /> (Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
- Subjects :
- Aged
Aged, 80 and over
Bacteriuria complications
Bacteriuria microbiology
Carcinoma, Transitional Cell complications
Carcinoma, Transitional Cell microbiology
Carcinoma, Transitional Cell pathology
Disease-Free Survival
Female
Humans
Male
Middle Aged
Neoplasm Recurrence, Local
Nephroureterectomy
Pyuria complications
Risk Factors
Urothelium microbiology
Urothelium pathology
Bacteriuria pathology
Carcinoma, Transitional Cell surgery
Pyuria pathology
Urothelium surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1791-7549
- Volume :
- 31
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- In vivo (Athens, Greece)
- Publication Type :
- Academic Journal
- Accession number :
- 29102949
- Full Text :
- https://doi.org/10.21873/invivo.11193