Back to Search
Start Over
Leukocyte telomere length variation in different stages of schizophrenia.
- Source :
-
Journal of psychiatric research [J Psychiatr Res] 2018 Jan; Vol. 96, pp. 218-223. Date of Electronic Publication: 2017 Oct 21. - Publication Year :
- 2018
-
Abstract
- Recent research has demonstrated that telomere maintenance might be a key integrating point for the cumulative effect of genetic and environmental factors in patients with first-episode psychosis (FEP) and schizophrenia (SCZ). Eighty-one participants with antipsychotic-naïve FEP, 173 with SCZ and 438 HC were enrolled in this study. Psychiatric diagnosis was assessed using the Semi-Structured Clinical Interview for DSM-IV Axis-I (SCID-I). The Positive and Negative Syndrome Scale (PANSS), Young Mania Rating Scale (YMRS) and Calgary Depression Scale for Schizophrenia (CDSS) were used to measure symptoms severity. Telomere length (TL) was determined using a multiplex qPCR assay. After adjustment for age, years of education, and smoking status, we found that patients with SCZ had longer TL (relative ratio (RR) = 1.08) than the HC group (RR = 1.00, Wald χ <superscript>2</superscript>  = 12.48, p = 0.002). Further, non-remitted SCZ patients presented longer TL (RR = 1.00) compared to remitted SCZ (RR = 0.88, Wald χ <superscript>2</superscript>  = 7.20, p = 0.007). TL in patients also correlated to psychopathology assessment in terms of total (p = 0.003) and positive PANSS scores (p = 0.001). No correlation with negative PANSS, YMRS, and CDSS or effects of medication was found on TL. Although the exact pathways underlying longer TL in SCZ patients remain unclear, these findings raise more questions than answers and suggest that TL may be of immense value on SCZ progression. Further studies are required to investigate the association of TL in FEP and SCZ.<br /> (Copyright © 2017 Elsevier Ltd. All rights reserved.)
- Subjects :
- Acute Disease
Adult
Chronic Disease
Educational Status
Female
Humans
Interview, Psychological
Linear Models
Male
Middle Aged
Polymerase Chain Reaction
Psychiatric Status Rating Scales
Schizophrenia genetics
Severity of Illness Index
Smoking genetics
Smoking metabolism
Telomere Shortening
Young Adult
Leukocytes metabolism
Schizophrenia metabolism
Telomere metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1379
- Volume :
- 96
- Database :
- MEDLINE
- Journal :
- Journal of psychiatric research
- Publication Type :
- Academic Journal
- Accession number :
- 29102816
- Full Text :
- https://doi.org/10.1016/j.jpsychires.2017.10.016