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Regulation of inflammatory pathways in schizophrenia: A comparative study with bipolar disorder and healthy controls.
- Source :
-
European psychiatry : the journal of the Association of European Psychiatrists [Eur Psychiatry] 2018 Jan; Vol. 47, pp. 50-59. Date of Electronic Publication: 2017 Oct 18. - Publication Year :
- 2018
-
Abstract
- Background: Immune-inflammatory processes have been implicated in schizophrenia (SCH), but their specificity is not clear.<br />Main Aim: To identify potential differential intra-/intercellular biochemical pathways controlling immune-inflammatory response and their oxidative-nitrosative impact on SCH patients, compared with bipolar disorder (BD) patients and healthy controls (HC).<br />Methods: Cross-sectional, naturalistic study of a cohort of SCH patients (n=123) and their controls [BD (n=102) and HC (n=80)].<br />Statistical Analysis: ANCOVA (or Quade test) controlling for age and gender when comparing the three groups, and controlling for age, gender, length of illness, cigarettes per day, and body mass index (BMI) when comparing SCH and BD.<br />Results: Pro-inflammatory biomarkers: Expression of COX-1 was statistically higher in SCH and BD than HC (P<0.0001; P<0.0001); NFκB and PGE2 were statistically higher in SCH compared with BD (P=0.001; P<0.0001) and HC (P=0.003; P<0.0001); NLRP3 was higher in BD than HC (P=0.005); and CPR showed a gradient among the three groups. Anti-inflammatory biomarkers: BD patients had lower PPARγ and higher 15d-PGJ2 levels than SCH (P=0.005; P=0.008) and HC (P=0.001; P=0.001). Differences between SCH and BD: previous markers of SCH (NFκB and PGE2) and BD (PPARγ and 15d-PGJ2) remained statistically significant and, interestingly, iNOS and COX-2 (pro-inflammatory biomarkers) levels were statistically higher in SCH than BD (P=0.019; P=0.040).<br />Conclusions: This study suggests a specific immune-inflammatory biomarker pattern for established SCH (NFκB, PGE2, iNOS, and COX-2) that differentiates it from BD and HC. In future, their pharmacological modulation may constitute a promising therapeutic target.<br /> (Copyright © 2017 Elsevier Masson SAS. All rights reserved.)
- Subjects :
- Adult
Biomarkers analysis
Bipolar Disorder pathology
Bipolar Disorder psychology
Case-Control Studies
Cross-Sectional Studies
Female
Humans
Inflammation pathology
Inflammation psychology
Male
Middle Aged
PPAR gamma analysis
Prostaglandin D2 analogs & derivatives
Prostaglandin D2 analysis
Schizophrenia pathology
Schizophrenic Psychology
Young Adult
Bipolar Disorder immunology
Bipolar Disorder metabolism
Inflammation immunology
Inflammation metabolism
Schizophrenia immunology
Schizophrenia metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1778-3585
- Volume :
- 47
- Database :
- MEDLINE
- Journal :
- European psychiatry : the journal of the Association of European Psychiatrists
- Publication Type :
- Academic Journal
- Accession number :
- 29102659
- Full Text :
- https://doi.org/10.1016/j.eurpsy.2017.09.007