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Trends in Antibiotic Susceptibility in Staphylococcus aureus in Boston, Massachusetts, from 2000 to 2014.
- Source :
-
Journal of clinical microbiology [J Clin Microbiol] 2017 Dec 26; Vol. 56 (1). Date of Electronic Publication: 2017 Dec 26 (Print Publication: 2018). - Publication Year :
- 2017
-
Abstract
- The rate of infection by methicillin-resistant Staphylococcus aureus (MRSA) has declined over the past decade, but it is unclear whether this represents a decline in S. aureus infections overall. To evaluate the trends in the annual rates of infection by S. aureus subtypes and mean antibiotic resistance, we conducted a 15-year retrospective observational study at two tertiary care institutions in Boston, MA, of 31,753 adult inpatients with S. aureus isolated from clinical specimens. We inferred the gain and loss of methicillin resistance through genome sequencing of 180 isolates from 2016. The annual rates of infection by S. aureus declined from 2003 to 2014 by 4.2% (2.7% to 5.6%), attributable to an annual decline in MRSA of 10.9% (9.3% to 12.6%). Penicillin-susceptible S. aureus (PSSA) increased by 6.1% (4.2% to 8.1%) annually, and rates of methicillin-susceptible penicillin-resistant S. aureus (MSSA) did not change. Resistance in S. aureus decreased from 2000 to 2014 by 0.8 antibiotics (0.7 to 0.8). Within common MRSA clonal complexes, 3/14 MSSA and 2/21 PSSA isolates arose from the loss of resistance-conferring genes. Overall, in two tertiary care institutions in Boston, MA, a decline in S. aureus infections has been accompanied by a shift toward increased antibiotic susceptibility. The rise in PSSA makes penicillin an increasingly viable treatment option.<br /> (Copyright © 2017 Kanjilal et al.)
- Subjects :
- Adult
Aged
Boston epidemiology
Female
Genome, Bacterial genetics
Humans
Male
Methicillin-Resistant Staphylococcus aureus drug effects
Methicillin-Resistant Staphylococcus aureus genetics
Microbial Sensitivity Tests
Middle Aged
Retrospective Studies
Staphylococcus aureus genetics
Tertiary Care Centers
Anti-Bacterial Agents pharmacology
Drug Resistance, Bacterial drug effects
Drug Resistance, Bacterial genetics
Molecular Epidemiology trends
Staphylococcal Infections epidemiology
Staphylococcal Infections microbiology
Staphylococcus aureus drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1098-660X
- Volume :
- 56
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of clinical microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 29093105
- Full Text :
- https://doi.org/10.1128/JCM.01160-17