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[Inhibition of the Janus kinase-signal transducer and activator of transcription is a new treatment modality of rheumatoid arthritis].
- Source :
-
Ugeskrift for laeger [Ugeskr Laeger] 2017 Oct 30; Vol. 179 (44). - Publication Year :
- 2017
-
Abstract
- Rheumatoid arthritis (RA) is a chronic inflammatory joint disease. The introduction of a new class of disease-modifying anti-rheumatic drugs, which work by inhibiting the Janus kinase-signal transducer and activator of transcription (JAK/STAT) pathway, has led to new possibilities for achieving remission of RA. Tofacitinib and baricitinib are both JAK/STAT inhibitors, which have shown efficacy in line with anti-tumour necrosis factor treatment. The side effects seem manageable, and up to now only increased risk of herpes zoster has raised consideration. JAK/STAT inhibitors create new possibilities for reaching low disease activity or remission for patients with RA.
- Subjects :
- Arthritis, Rheumatoid physiopathology
Azetidines adverse effects
Azetidines pharmacokinetics
Azetidines therapeutic use
Herpes Zoster chemically induced
Humans
Piperidines adverse effects
Piperidines pharmacokinetics
Piperidines therapeutic use
Protein Kinase Inhibitors adverse effects
Protein Kinase Inhibitors pharmacokinetics
Protein Kinase Inhibitors therapeutic use
Purines
Pyrazoles
Pyrimidines adverse effects
Pyrimidines pharmacokinetics
Pyrimidines therapeutic use
Pyrroles adverse effects
Pyrroles pharmacokinetics
Pyrroles therapeutic use
Sulfonamides adverse effects
Sulfonamides pharmacokinetics
Sulfonamides therapeutic use
Antirheumatic Agents adverse effects
Antirheumatic Agents pharmacokinetics
Antirheumatic Agents therapeutic use
Arthritis, Rheumatoid drug therapy
Janus Kinase Inhibitors adverse effects
Janus Kinase Inhibitors pharmacokinetics
Janus Kinase Inhibitors therapeutic use
Subjects
Details
- Language :
- Danish
- ISSN :
- 1603-6824
- Volume :
- 179
- Issue :
- 44
- Database :
- MEDLINE
- Journal :
- Ugeskrift for laeger
- Publication Type :
- Academic Journal
- Accession number :
- 29084618