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Stage II recurrent nasopharyngeal carcinoma: Prognostic significance of retropharyngeal nodal metastasis, parapharyngeal invasion, and carotid encasement.
- Source :
-
Head & neck [Head Neck] 2018 Jan; Vol. 40 (1), pp. 103-110. Date of Electronic Publication: 2017 Oct 30. - Publication Year :
- 2018
-
Abstract
- Background: The purpose of this study was to assess the predictability of the American Joint Committee on Cancer (AJCC) staging system on patients with stage II recurrent nasopharyngeal carcinoma (NPC).<br />Method: We conducted a retrospective review of the surgical outcome for patients with recurrent NPC and retropharyngeal lymph node (RLN) metastasis (group I), recurrent NPC and parapharyngeal space (PPS) invasion (group II), and recurrent NPC and internal carotid artery (ICA) encasement (group III).<br />Results: Between 1990 and 2013, 145 patients received an operation for stage II recurrent NPC (group I, n = 62; group II, n = 65; and group III, n = 18). The rate of local tumor recurrence was significantly higher in groups II and III. The rate of systemic metastasis was significantly higher in group III (16.7%). Accordingly, the 5-year overall survival was significantly worse for patients in group III (group I: 81.2%; group II: 68.4%; and group III: 48.5%).<br />Conclusion: The significantly worse prognosis of recurrent NPC encasing the ICA warrants an upstage to the T3 classification in the current AJCC staging system.<br /> (© 2017 Wiley Periodicals, Inc.)
- Subjects :
- Adult
Aged
Cohort Studies
Disease-Free Survival
Female
Humans
Lymph Nodes surgery
Lymphatic Metastasis
Magnetic Resonance Imaging methods
Male
Middle Aged
Nasopharyngeal Neoplasms mortality
Nasopharyngeal Neoplasms radiotherapy
Neoplasm Invasiveness pathology
Neoplasm Recurrence, Local mortality
Neoplasm Recurrence, Local surgery
Neoplasm Staging
Pharyngectomy methods
Positron-Emission Tomography methods
Prognosis
Retrospective Studies
Risk Assessment
Survival Analysis
Treatment Outcome
Young Adult
Carotid Arteries pathology
Lymph Nodes pathology
Nasopharyngeal Neoplasms pathology
Nasopharyngeal Neoplasms surgery
Neoplasm Recurrence, Local pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0347
- Volume :
- 40
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Head & neck
- Publication Type :
- Academic Journal
- Accession number :
- 29083514
- Full Text :
- https://doi.org/10.1002/hed.24976