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Human B Regulatory Cells: The New Players in Autoimmune Disease.

Authors :
Maravillas-Montero JL
Acevedo-Ochoa E
Source :
Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion [Rev Invest Clin] 2017 Sep-Oct; Vol. 69 (5), pp. 243-246.
Publication Year :
2017

Abstract

Although the production of antigen-specific antibodies has been the originally accepted function of B-cells during immune responses, specific subsets that can negatively regulate inflammation, designated regulatory B-cells (Bregs), have been identified recently. These immunosuppressive cells support tolerance, mainly through the production of interleukin 10 and other unconventional factors. There have been emerging data suggesting their importance in diverse normal and pathologic processes. Novel and in development B-cell targeted therapies seem to be ideal treatments for different types of diseasessuch as cancer and allergy. Here, we discuss the current knowledge on the implication of Bregs in autoimmunity- elated diseases, highlighting the importance of these cells for the development of novel strategies in the treatment of these pathologies.

Details

Language :
English
ISSN :
0034-8376
Volume :
69
Issue :
5
Database :
MEDLINE
Journal :
Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion
Publication Type :
Academic Journal
Accession number :
29077695
Full Text :
https://doi.org/10.24875/ric.17002266