Back to Search
Start Over
Assessment of laryngeal cancer in patients younger than 40 years.
- Source :
-
The Laryngoscope [Laryngoscope] 2018 Jul; Vol. 128 (7), pp. 1602-1605. Date of Electronic Publication: 2017 Oct 27. - Publication Year :
- 2018
-
Abstract
- Objectives/hypothesis: To assess the differences between patients with laryngeal squamous cell carcinoma under 40 years old and those 40 years old or older. A secondary objective was to compare survival outcome between these cohorts.<br />Study Design: Retrospective chart review.<br />Methods: We reviewed the medical charts of all patients treated in our tertiary referral center for laryngeal squamous cell carcinoma from 2005 to 2014. Patients aged < 40 years at diagnosis were compared to older patients.<br />Results: The study group comprised 160 patients. Of them, 13 were aged < 40 years at diagnosis. Mean age was 35 ± 3.9 years and 64.4 ± 11 years for the two groups. Among the younger patients, 38% were smokers (mean pack/day, 2.2) versus 71% in the older group (mean pack/day, 3). The younger group typically had a more advanced stage than the older group at presentation; eight young patients (62%) had stage III or IV versus 49 (33%) in the older group (P = .042). Mean overall survival was 6.7 ± 1 years for those under 40 years old and 7.7 ± 0.2 years for the older patients (P = .2). The 5-year survival rate was 69% for young patients and 90% for the older group (P = .04). However, there was no significant between-group difference in overall survival or 5-year survival rate when stratified for early- and late-stage disease.<br />Conclusions: There is a lower prevalence of classic risk factors in younger patient with laryngeal carcinoma in this study, suggesting a different etiology compared to our older cohort. The under-40 cohort presented with more advanced disease and had a worse 5-year survival; however, when stratified for early- versus late-stage disease, there was no significant difference in overall or 5-year survival between the groups. This may suggest that, despite a different etiology, laryngeal cancer behaves similarly in older and younger patients.<br />Level of Evidence: 4. Laryngoscope, 128:1602-1605, 2018.<br /> (© 2017 The American Laryngological, Rhinological and Otological Society, Inc.)
- Subjects :
- Adult
Age Factors
Aged
Carcinoma, Squamous Cell pathology
Carcinoma, Squamous Cell therapy
Female
Humans
Laryngeal Neoplasms pathology
Laryngeal Neoplasms therapy
Male
Middle Aged
Neoplasm Staging
Retrospective Studies
Risk Factors
Survival Rate
Carcinoma, Squamous Cell mortality
Laryngeal Neoplasms mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1531-4995
- Volume :
- 128
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- The Laryngoscope
- Publication Type :
- Academic Journal
- Accession number :
- 29076536
- Full Text :
- https://doi.org/10.1002/lary.26951