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Traffic-related air pollution exposure over a 5-year period is associated with increased risk of asthma and poor lung function in middle age.
- Source :
-
The European respiratory journal [Eur Respir J] 2017 Oct 26; Vol. 50 (4). Date of Electronic Publication: 2017 Oct 26 (Print Publication: 2017). - Publication Year :
- 2017
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Abstract
- Current evidence concerning the impact of exposure to traffic-related air pollution (TRAP) on adult respiratory morbidity mainly comes from cross-sectional studies. We sought to establish more robust measures of this association and potential gene-environment interactions using longitudinal data from an established cohort study.Associations between measures of TRAP (nitrogen dioxide (NO <subscript>2</subscript> ) and distance to major roads) and wheeze, asthma prevalence and lung function were investigated in participants of the Tasmanian Longitudinal Health Study at 45- and 50-year follow-ups. Generalised estimating equations were used to quantify associations and the potential modifying effect of glutathione S -transferase gene variants.Living <200 m from a major road was associated with increased prevalence of current asthma and wheeze, and lower lung function. The association between living <200 m from a major road and current asthma and wheeze was more marked for carriers of the GSTT1 null and GSTP1 val / val or ile / val genotypes. Over the 5-year period, higher NO <subscript>2</subscript> exposures were associated with increased current asthma prevalence. Higher NO <subscript>2</subscript> exposure was associated with lower forced vital capacity for carriers of the GSTT1 null genotype.TRAP exposures were associated with increased risk of asthma, wheeze and lower lung function in middle-aged adults. The interaction with the GSTT1 genotype suggests that deficient antioxidant mechanisms may play a role in these adverse health effects.<br />Competing Interests: Conflict of interest: Disclosures can be found alongside this article at erj.ersjournals.com<br /> (Copyright ©ERS 2017.)
- Subjects :
- Asthma physiopathology
Australia epidemiology
Cross-Sectional Studies
Female
Gene-Environment Interaction
Glutathione Transferase genetics
Heterozygote
Humans
Logistic Models
Longitudinal Studies
Male
Middle Aged
Multivariate Analysis
Respiratory Sounds etiology
Risk Assessment
Severity of Illness Index
Vital Capacity
Air Pollution adverse effects
Asthma epidemiology
Environmental Exposure adverse effects
Lung physiopathology
Nitrogen Dioxide analysis
Subjects
Details
- Language :
- English
- ISSN :
- 1399-3003
- Volume :
- 50
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The European respiratory journal
- Publication Type :
- Academic Journal
- Accession number :
- 29074540
- Full Text :
- https://doi.org/10.1183/13993003.02357-2016