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Rapid Laboratory Identification of Neisseria meningitidis Serogroup C as the Cause of an Outbreak - Liberia, 2017.
- Source :
-
MMWR. Morbidity and mortality weekly report [MMWR Morb Mortal Wkly Rep] 2017 Oct 27; Vol. 66 (42), pp. 1144-1147. Date of Electronic Publication: 2017 Oct 27. - Publication Year :
- 2017
-
Abstract
- On April 25, 2017, a cluster of unexplained illness and deaths among persons who had attended a funeral during April 21-22 was reported in Sinoe County, Liberia (1). Using a broad initial case definition, 31 cases were identified, including 13 (42%) deaths. Twenty-seven cases were from Sinoe County (1), and two cases each were from Grand Bassa and Monsterrado counties, respectively. On May 5, 2017, initial multipathogen testing of specimens from four fatal cases using the Taqman Array Card (TAC) assay identified Neisseria meningitidis in all specimens. Subsequent testing using direct real-time polymerase chain reaction (PCR) confirmed N. meningitidis in 14 (58%) of 24 patients with available specimens and identified N. meningitidis serogroup C (NmC) in 13 (54%) patients. N. meningitidis was detected in specimens from 11 of the 13 patients who died; no specimens were available from the other two fatal cases. On May 16, 2017, the National Public Health Institute of Liberia and the Ministry of Health of Liberia issued a press release confirming serogroup C meningococcal disease as the cause of this outbreak in Liberia.
- Subjects :
- Clinical Laboratory Services statistics & numerical data
Cluster Analysis
Humans
Liberia epidemiology
Meningitis, Meningococcal mortality
Real-Time Polymerase Chain Reaction
Time Factors
Disease Outbreaks
Meningitis, Meningococcal epidemiology
Meningitis, Meningococcal microbiology
Neisseria meningitidis, Serogroup C isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 1545-861X
- Volume :
- 66
- Issue :
- 42
- Database :
- MEDLINE
- Journal :
- MMWR. Morbidity and mortality weekly report
- Publication Type :
- Academic Journal
- Accession number :
- 29073124
- Full Text :
- https://doi.org/10.15585/mmwr.mm6642a5