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Red cell distribution width predicts death and appropriate therapy in patients with implantable cardioverter defibrillator: A simple measurement with prognostic value in a variety of diseases, may help in better selection of patients who will benefit the most from this device.
- Source :
-
Pacing and clinical electrophysiology : PACE [Pacing Clin Electrophysiol] 2017 Dec; Vol. 40 (12), pp. 1384-1388. Date of Electronic Publication: 2017 Nov 19. - Publication Year :
- 2017
-
Abstract
- Background: Red cell distribution width (RDW) is a measure of the size variation of erythrocytes. Its prognostic value has been described in a variety of cardiac and noncardiac diseases. Implantable cardioverter defibrillator (ICD) is useful in preventing sudden cardiac death in high-risk patients, but many of these patients continue to survive without needing ICD therapy. We sought to examine whether RDW, with its prognostic values, can benefit in risk stratification of patients with ICD by predicting death and ICD therapy, and thus help in the selection of patients who will benefit the most from ICD, and minimizing its implantation in others at low risk of death and arrhythmias.<br />Methods: In a retrospective study, we enrolled patients with ICD implanted for both primary and secondary prevention of sudden cardiac death. Baseline RDW values, demographics, and clinical characteristics, as well as the occurrence of death or first appropriate ICD therapy in postimplantation follow-up were collected. We examined whether RDW can predict higher-risk ICD-implanted patients prone to death and first appropriate ICD therapy (the combined outcome).<br />Results: Final population included 432 patients. Compared to others, patients in the upper RDW tertile were older and had more comorbidities and outcomes. In multivariate analysis including RDW, age, gender, and ejection fraction, RDW was the only predictor of the combined outcome.<br />Conclusion: RDW may be useful in risk stratification of patients selected for ICD implantation. But larger prospective randomized trials are needed.<br /> (© 2017 Wiley Periodicals, Inc.)
- Subjects :
- Aged
Arrhythmias, Cardiac complications
Death, Sudden, Cardiac etiology
Female
Humans
Male
Middle Aged
Predictive Value of Tests
Prognosis
Retrospective Studies
Risk Assessment
Arrhythmias, Cardiac therapy
Death, Sudden, Cardiac prevention & control
Defibrillators, Implantable
Erythrocyte Indices
Patient Selection
Subjects
Details
- Language :
- English
- ISSN :
- 1540-8159
- Volume :
- 40
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Pacing and clinical electrophysiology : PACE
- Publication Type :
- Academic Journal
- Accession number :
- 29067703
- Full Text :
- https://doi.org/10.1111/pace.13226