Emergence of ArmA, a 16S rRNA methylase in highly aminoglycoside-resistant clinical isolates of Klebsiella pneumoniae and Klebsiella oxytoca in Okinawa, Japan.

Authors :: Uechi K
Tada T
Shimada K
Nakasone I
Sonozaki T
Kirikae T
Fujita J
Source :: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy [J Infect Chemother] 2018 Jan; Vol. 24 (1), pp. 68-70. Date of Electronic Publication: 2017 Oct 21.
Publication Year :: 2018
Abstract: This study describes highly aminoglycoside-resistant Klebsiella pneumoniae and Klebsiella oxytoca clinical isolates obtained from an inpatient in Okinawa, Japan, with no known record of traveling overseas. The minimum inhibitory concentrations of amikacin and arbekacin against these strains were >1024 μg/ml. Whole-genome sequencing analysis revealed that these isolates harbored armA, which encodes a 16S rRNA methylase, ArmA, that confers pan-aminoglycoside resistance. This is the second report of K. pneumoniae harboring armA and the first report of K. oxytoca harboring a 16S rRNA methylase encoding gene in Japan.<br /> (Copyright © 2017 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.)

Language :: English
ISSN :: 1437-7780
Volume :: 24
Issue :: 1
Database :: MEDLINE
Journal :: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
Publication Type :: Academic Journal
Accession number :: 29066218
Full Text :: https://doi.org/10.1016/j.jiac.2017.09.006

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