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The oxygen uptake efficiency slope is not a valid surrogate of aerobic fitness in cystic fibrosis.
- Source :
-
Pediatric pulmonology [Pediatr Pulmonol] 2018 Jan; Vol. 53 (1), pp. 36-42. Date of Electronic Publication: 2017 Oct 24. - Publication Year :
- 2018
-
Abstract
- Background: Maximal cardiopulmonary exercise testing is recommended on an annual basis for children with cystic fibrosis (CF), due to clinically useful prognostic information provided by maximal oxygen uptake (V̇O <subscript>2max</subscript> ). However, not all patients are able, or willing, to reach V̇O <subscript>2max</subscript> , and therefore submaximal alternatives are required. This study explored the validity of the oxygen uptake efficiency slope (OUES) as a submaximal measure of V̇O <subscript>2max</subscript> in children and adolescents with CF.<br />Methods: Data were collated from 72 cardiopulmonary exercise tests (36 CF, 36 controls), with OUES determined relative to maximal and submaximal parameters of exercise intensity, time, and individual metabolic thresholds. Pearson's correlation coefficients, independent t-tests, and factorial ANOVAs were used to determine validity.<br />Results: Significant (P < 0.05) correlations with V̇O <subscript>2max</subscript> were observed for most expressions of OUES, but were consistently weaker in CF (r = 0.30-0.47) when compared to CON (r = 0.58-0.89). Mean differences for all OUES parameters between groups were not significant (P > 0.05). When split by V̇O <subscript>2max</subscript> tertiles, minimal significant differences were found between, and within, groups for OUES, indicating poor discrimination of V̇O <subscript>2max</subscript> .<br />Conclusions: The OUES is not a valid (sub) maximal measure of V̇O <subscript>2max</subscript> in children and adolescents with mild-to-moderate CF. Clinicians should continue to use maximal markers (ie, V̇O <subscript>2max</subscript> ) of exercise capacity.<br /> (© 2017 Wiley Periodicals, Inc.)
Details
- Language :
- English
- ISSN :
- 1099-0496
- Volume :
- 53
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Pediatric pulmonology
- Publication Type :
- Academic Journal
- Accession number :
- 29064163
- Full Text :
- https://doi.org/10.1002/ppul.23896