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Mother-to-infant transmission of hepatitis B virus: challenges and perspectives.
- Source :
-
Hepatology international [Hepatol Int] 2017 Nov; Vol. 11 (6), pp. 481-484. Date of Electronic Publication: 2017 Oct 24. - Publication Year :
- 2017
-
Abstract
- Chronic hepatitis B virus (HBV) infection due to perinatal mother-to-infant transmission (MTIT) remains a serious global health problem. Despite passive-active immunoprophylaxis using hepatitis B vaccination with or without hepatitis B immunoglobulin (HBIg), up to 8-10% of newborns still acquire HBV infection. Understanding the mechanisms of MTIT is essential for the interruption of HBV transmission. There are three possible routes of transmission: intrauterine transmission, transmission during delivery (intrapartum) and postnatal transmission through close contact or breast milk (postpartum). Overall, positivity for hepatitis B e antigen (HBeAg) and the high viral load of the mothers are the two most important risk factors related to MTIT of HBV. This article briefly reviews the viral factors related to MTIT of HBV and discusses the issues that warrant further investigation.
- Subjects :
- Antiviral Agents therapeutic use
Female
Genotype
Hepatitis B virus genetics
Hepatitis B, Chronic blood
Hepatitis B, Chronic drug therapy
Humans
Infant, Newborn
Practice Guidelines as Topic
Pregnancy
Pregnancy Complications, Infectious virology
Pregnancy Trimester, Third
Hepatitis B, Chronic prevention & control
Hepatitis B, Chronic transmission
Infectious Disease Transmission, Vertical
Pregnancy Complications, Infectious blood
Vaccination
Viral Load
Subjects
Details
- Language :
- English
- ISSN :
- 1936-0541
- Volume :
- 11
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Hepatology international
- Publication Type :
- Academic Journal
- Accession number :
- 29064028
- Full Text :
- https://doi.org/10.1007/s12072-017-9831-0