Update on investigations pertaining to the pathogenesis of biliary atresia.

Authors :: Kilgore A
Mack CL
Source :: Pediatric surgery international [Pediatr Surg Int] 2017 Dec; Vol. 33 (12), pp. 1233-1241. Date of Electronic Publication: 2017 Oct 24.
Publication Year :: 2017
Abstract: Biliary atresia is a devastating biliary disease of neonates that results in liver transplantation for the vast majority. The etiology of biliary atresia is unknown and is likely multifactorial, with components of genetic predisposition, environmental trigger and autoimmunity contributing to disease pathogenesis. This review highlights recent work related to investigations of disease pathogenesis in biliary atresia.