Taming photo-induced oxidation degradation of dihydropyridine drugs through cocrystallization.

Authors :: Yu Q
Yan Z
Bao J
Wang JR
Mei X
Source :: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2017 Nov 14; Vol. 53 (91), pp. 12266-12269.
Publication Year :: 2017
Abstract: Cocrystallization of nifedipine (NFD) and isonicotinamide (INA) resulted in two monotropic cocrystal polymorphs. The thermodynamically more stable polymorph presents superior photostability compared to the other. Cocrystallization can be an efficient approach to address the stability deficit of dihydropyridine drugs.

Subjects :: Crystallization
Molecular Conformation
Oxidation-Reduction
Photochemical Processes
Thermodynamics
Calcium Channel Blockers chemistry
Dihydropyridines chemistry
Niacinamide chemistry
Nifedipine chemistry

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