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A decrease in serum 1,5-anhydroglucitol levels is associated with the presence of a first-degree family history of diabetes in a Chinese population with normal glucose tolerance.
- Source :
-
Diabetic medicine : a journal of the British Diabetic Association [Diabet Med] 2018 Jan; Vol. 35 (1), pp. 131-136. Date of Electronic Publication: 2017 Nov 13. - Publication Year :
- 2018
-
Abstract
- Aim: This study aimed to investigate alterations in HbA <subscript>1c</subscript> , glycated albumin (GA) and 1,5-anhydroglucitol (1,5-AG) in Chinese first-degree relatives of individuals with diabetes (FDR) in pursuit of an index for early screening of glucose metabolism disturbance.<br />Methods: A total of 467 participants (age range: 20-78 years) with normal weight and normal glucose tolerance, as determined by a 75-g oral glucose tolerance test, were enrolled. HbA <subscript>1c</subscript> was measured using high-performance liquid chromatography. Serum GA and 1,5-AG levels were determined by enzymatic methods. Serum insulin levels were measured using an electrochemiluminescence immunoassay.<br />Results: The study population included 208 FDR and 259 non-FDR. Serum 1,5-AG levels were lower in FDR than that in non-FDR (20.4 ± 7.5 vs 23.8 ± 8.3 μg/ml, P < 0.001), but HbA <subscript>1c</subscript> and GA levels did not differ between them (P = 0.835 and 0.469, respectively). Logistic regression analysis revealed an independent relationship between a first-degree family history of diabetes and reduced serum 1,5-AG levels (odds ratio = 0.944, P < 0.001). Multiple regression analysis showed that a first-degree family history of diabetes (β = -3.041, P < 0.001) and insulinogenic index (β = 0.081, P = 0.001) were independently associated with serum 1,5-AG levels.<br />Conclusion: In a Chinese population with normal glucose tolerance, serum 1,5-AG levels were lower among FDR, and serum 1,5-AG levels were independently associated with FDR status. For FDR, serum 1,5-AG levels were more sensitive than HbA <subscript>1c</subscript> or GA levels to early-phase abnormality in glucose metabolism.<br /> (© 2017 Diabetes UK.)
- Subjects :
- Adult
Aged
Asian People
China
Chromatography, High Pressure Liquid
Diabetes Mellitus, Type 2 metabolism
Female
Glucose Tolerance Test
Glycation End Products, Advanced
Humans
Logistic Models
Male
Middle Aged
Young Adult
Glycated Serum Albumin
Deoxyglucose blood
Diabetes Mellitus, Type 2 blood
Family
Glycated Hemoglobin metabolism
Serum Albumin metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1464-5491
- Volume :
- 35
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Diabetic medicine : a journal of the British Diabetic Association
- Publication Type :
- Academic Journal
- Accession number :
- 29057494
- Full Text :
- https://doi.org/10.1111/dme.13534