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Cross-talk between the epigenome and neural circuits in drug addiction.

Authors :
Mews P
Calipari ES
Source :
Progress in brain research [Prog Brain Res] 2017; Vol. 235, pp. 19-63. Date of Electronic Publication: 2017 Sep 28.
Publication Year :
2017

Abstract

Drug addiction is a behavioral disorder characterized by dysregulated learning about drugs and associated cues that result in compulsive drug seeking and relapse. Learning about drug rewards and predictive cues is a complex process controlled by a computational network of neural connections interacting with transcriptional and molecular mechanisms within each cell to precisely guide behavior. The interplay between rapid, temporally specific neuronal activation, and longer-term changes in transcription is of critical importance in the expression of appropriate, or in the case of drug addiction, inappropriate behaviors. Thus, these factors and their interactions must be considered together, especially in the context of treatment. Understanding the complex interplay between epigenetic gene regulation and circuit connectivity will allow us to formulate novel therapies to normalize maladaptive reward behaviors, with a goal of modulating addictive behaviors, while leaving natural reward-associated behavior unaffected.<br /> (© 2017 Elsevier B.V. All rights reserved.)

Details

Language :
English
ISSN :
1875-7855
Volume :
235
Database :
MEDLINE
Journal :
Progress in brain research
Publication Type :
Academic Journal
Accession number :
29054289
Full Text :
https://doi.org/10.1016/bs.pbr.2017.08.012