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TβRIII is induced by TCR signaling and downregulated in FoxP3 + regulatory T cells.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2017 Dec 09; Vol. 494 (1-2), pp. 82-87. Date of Electronic Publication: 2017 Oct 16. - Publication Year :
- 2017
-
Abstract
- TGF-β type III receptor (TβRIII) is a co-receptor for TGFβ family members required for high-affinity binding of these ligands to their receptors, potentiating their cellular functions. TGF-βs, Bone Morphogenetic Proteins (BMP2/4) and Inhibins/Activins regulate different checkpoints during T cell differentiation. We have previously reported that TβRIII modulates T cell development by protecting developing thymocytes from apoptosis, however the role of this co-receptor in peripheral lymphocytes still remains elusive. Here we describe a detailed characterization of TβRIII expression in murine and human lymphocyte subpopulations demonstrating that this co-receptor is significantly expressed in T but not B lymphocytes and among them, preferentially expressed on naïve and central memory T cells. TβRIII was upregulated after TCR stimulation, in parallel to other early activation markers. In contrast, natural and induced Tregs downregulated TβRIII in association with FoxP3 upregulation. Finally, anti-TβRIII blocking experiments demonstrated that TβRIII promotes TGFβ-dependent iTreg conversion in vitro, and suggest that this co-receptor may be involved in modulating peripheral T cell tolerance and could be considered as a potential target to boost T cell immune responses.<br /> (Copyright © 2017. Published by Elsevier Inc.)
- Subjects :
- Animals
Down-Regulation
Forkhead Transcription Factors metabolism
Humans
Immunologic Memory
In Vitro Techniques
Lymphocyte Activation
Mice
Mice, Inbred C57BL
Mice, Transgenic
Proteoglycans antagonists & inhibitors
Proteoglycans genetics
Receptors, Transforming Growth Factor beta antagonists & inhibitors
Receptors, Transforming Growth Factor beta genetics
Signal Transduction
T-Lymphocytes, Regulatory classification
T-Lymphocytes, Regulatory metabolism
Up-Regulation
Proteoglycans metabolism
Receptors, Antigen, T-Cell metabolism
Receptors, Transforming Growth Factor beta metabolism
T-Lymphocytes, Regulatory immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2104
- Volume :
- 494
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 29050936
- Full Text :
- https://doi.org/10.1016/j.bbrc.2017.10.081