Back to Search Start Over

TβRIII is induced by TCR signaling and downregulated in FoxP3 + regulatory T cells.

Authors :
Ortega-Francisco S
de la Fuente-Granada M
Alvarez Salazar EK
Bolaños-Castro LA
Fonseca-Camarillo G
Olguin-Alor R
Alemán-Muench GR
López-Casillas F
Raman C
García-Zepeda EA
Soldevila G
Source :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2017 Dec 09; Vol. 494 (1-2), pp. 82-87. Date of Electronic Publication: 2017 Oct 16.
Publication Year :
2017

Abstract

TGF-β type III receptor (TβRIII) is a co-receptor for TGFβ family members required for high-affinity binding of these ligands to their receptors, potentiating their cellular functions. TGF-βs, Bone Morphogenetic Proteins (BMP2/4) and Inhibins/Activins regulate different checkpoints during T cell differentiation. We have previously reported that TβRIII modulates T cell development by protecting developing thymocytes from apoptosis, however the role of this co-receptor in peripheral lymphocytes still remains elusive. Here we describe a detailed characterization of TβRIII expression in murine and human lymphocyte subpopulations demonstrating that this co-receptor is significantly expressed in T but not B lymphocytes and among them, preferentially expressed on naïve and central memory T cells. TβRIII was upregulated after TCR stimulation, in parallel to other early activation markers. In contrast, natural and induced Tregs downregulated TβRIII in association with FoxP3 upregulation. Finally, anti-TβRIII blocking experiments demonstrated that TβRIII promotes TGFβ-dependent iTreg conversion in vitro, and suggest that this co-receptor may be involved in modulating peripheral T cell tolerance and could be considered as a potential target to boost T cell immune responses.<br /> (Copyright © 2017. Published by Elsevier Inc.)

Details

Language :
English
ISSN :
1090-2104
Volume :
494
Issue :
1-2
Database :
MEDLINE
Journal :
Biochemical and biophysical research communications
Publication Type :
Academic Journal
Accession number :
29050936
Full Text :
https://doi.org/10.1016/j.bbrc.2017.10.081