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Management of the lateral neck compartment in patients with sporadic medullary thyroid cancer.
Management of the lateral neck compartment in patients with sporadic medullary thyroid cancer.
- Source :
-
Head & neck [Head Neck] 2018 Jan; Vol. 40 (1), pp. 79-85. Date of Electronic Publication: 2017 Oct 16. - Publication Year :
- 2018
-
Abstract
- Background: The purpose of this retrospective analysis was to evaluate the benefits of an elective lateral neck dissection (ELND) in patients with medullary thyroid cancer (MTC) without radiographically apparent lateral neck metastases.<br />Methods: Patients with sporadic MTC without radiographic evidence of lateral neck metastasis who underwent definitive surgery were divided into 2 groups based on surgical approach: no ELND (the observation group) and ipsilateral or bilateral ELND (the ELND group). Primary outcomes were biochemical cure, locoregional recurrence, distant metastasis, and overall survival (OS).<br />Results: Sixty-six patients met inclusion criteria: 44 patients (67%) in the observation group and 22 patients (33%) in the ELND group. Two of 44 patients (5%) in the observation group developed subsequent (ipsilateral) lateral neck disease. At last follow-up, locoregional disease control rates among the observation and ELND groups were 98% and 100% (P > .999), respectively, whereas biochemical cure rates were 82% and 85% (P > .999), respectively, and 5-year OSs were 84% and 100% (P = .156), respectively.<br />Conclusion: Patients with MTC without lateral neck metastasis have similar biochemical cure rates with observation or elective dissection of lateral neck compartments.<br /> (© 2017 Wiley Periodicals, Inc.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Carcinoma, Neuroendocrine diagnostic imaging
Carcinoma, Neuroendocrine mortality
Carcinoma, Neuroendocrine pathology
Cause of Death
Cohort Studies
Disease Management
Disease-Free Survival
Elective Surgical Procedures mortality
Female
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Neck Dissection mortality
Neoplasm Invasiveness
Neoplasm Staging
Prognosis
Retrospective Studies
Risk Assessment
Statistics, Nonparametric
Survival Analysis
Thyroid Neoplasms diagnostic imaging
Thyroid Neoplasms mortality
Thyroid Neoplasms pathology
Tomography, X-Ray Computed methods
Watchful Waiting
Carcinoma, Neuroendocrine surgery
Elective Surgical Procedures methods
Neck Dissection methods
Thyroid Neoplasms surgery
Thyroidectomy methods
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0347
- Volume :
- 40
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Head & neck
- Publication Type :
- Academic Journal
- Accession number :
- 29044788
- Full Text :
- https://doi.org/10.1002/hed.24969