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Management of the lateral neck compartment in patients with sporadic medullary thyroid cancer.

Management of the lateral neck compartment in patients with sporadic medullary thyroid cancer.

Authors :
Pena I
Clayman GL
Grubbs EG
Bergeron JM Jr
Waguespack SG
Cabanillas ME
Dadu R
Hu MI
Fellman BM
Li Y
Gross ND
Lai SY
Sturgis EM
Zafereo ME
Source :
Head & neck [Head Neck] 2018 Jan; Vol. 40 (1), pp. 79-85. Date of Electronic Publication: 2017 Oct 16.
Publication Year :
2018

Abstract

Background: The purpose of this retrospective analysis was to evaluate the benefits of an elective lateral neck dissection (ELND) in patients with medullary thyroid cancer (MTC) without radiographically apparent lateral neck metastases.<br />Methods: Patients with sporadic MTC without radiographic evidence of lateral neck metastasis who underwent definitive surgery were divided into 2 groups based on surgical approach: no ELND (the observation group) and ipsilateral or bilateral ELND (the ELND group). Primary outcomes were biochemical cure, locoregional recurrence, distant metastasis, and overall survival (OS).<br />Results: Sixty-six patients met inclusion criteria: 44 patients (67%) in the observation group and 22 patients (33%) in the ELND group. Two of 44 patients (5%) in the observation group developed subsequent (ipsilateral) lateral neck disease. At last follow-up, locoregional disease control rates among the observation and ELND groups were 98% and 100% (P > .999), respectively, whereas biochemical cure rates were 82% and 85% (P > .999), respectively, and 5-year OSs were 84% and 100% (P = .156), respectively.<br />Conclusion: Patients with MTC without lateral neck metastasis have similar biochemical cure rates with observation or elective dissection of lateral neck compartments.<br /> (© 2017 Wiley Periodicals, Inc.)

Details

Language :
English
ISSN :
1097-0347
Volume :
40
Issue :
1
Database :
MEDLINE
Journal :
Head & neck
Publication Type :
Academic Journal
Accession number :
29044788
Full Text :
https://doi.org/10.1002/hed.24969