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Systematic review and meta-analysis of liver transplantation using grafts from deceased donors aged over 70 years.
- Source :
-
Clinical transplantation [Clin Transplant] 2017 Dec; Vol. 31 (12). Date of Electronic Publication: 2017 Nov 16. - Publication Year :
- 2017
-
Abstract
- Introduction: Due to the current organ shortage, nearly 20% of patients die waiting for a liver transplant (LT). The average donor age is on the rise, and grafts from elderly donors are offered as extended criteria grafts.<br />Methods: This is a meta-analysis comparing the outcome differences of adult patients undergoing LT using grafts from <70-year-old donors vs >70-year-old donors. The primary end-points were graft and patient survival. Secondary outcomes were biliary and vascular complications as well as graft function. The odds ratio (OR) is a summary statistic with the corresponding 95% confidence interval; P < .05 was considered to be statistically significant.<br />Results: Eight nonrandomized comparative studies with 4376 LT recipients were included. About 79.9% and 20.1% of the grafts were from <70-year-old and >70-year-old donors, respectively. Graft survival at 1 year was similar between the two groups (P = .11), but there was better 3-year and 5-year graft survival in the >70-year-old group (P = .006 and P < .0001, respectively). Patient survival was also similar between the groups at 1 year (P = .54), but with better survival at 3-year and 5-year follow-ups (P = .007 and P < .0001, respectively) in the >70-year-old group. There were no statistically significant differences in the incidence of biliary, vascular, and graft functional-related complications.<br />Conclusion: Liver grafts from selected >70-year-old donors do not pose added organ-specific risks and thus have comparable transplantation outcomes.<br /> (© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Subjects :
- Age Factors
Aged
Cadaver
Humans
Liver Transplantation
Tissue Donors
Subjects
Details
- Language :
- English
- ISSN :
- 1399-0012
- Volume :
- 31
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Clinical transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 29044682
- Full Text :
- https://doi.org/10.1111/ctr.13139