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Southeast asian ovalocytosis: the need for a carefull observation of red cell indices and blood smear.
- Source :
-
Annales de biologie clinique [Ann Biol Clin (Paris)] 2017 Dec 01; Vol. 75 (6), pp. 699-702. - Publication Year :
- 2017
-
Abstract
- Southeast asian ovalocytosis (SAO) is characterized by macro-ovalocytes and ovalo-stomatocytes on blood smear. SAO is common in Malaisia and Papua-New-Guinea where upwards to 40 per cent of the population is affected in some coastal region. Inherited in an autosomal dominant way, illness results from deletion of codons 400-408 in SLC4A1 gene which encodes for band 3 erythrocyte membrane protein. This deletion is responsible for an unusual erythrocyte stiffness and oval shape of the cells on blood smear. Heterozygous carriers are usually asymptomatic whereas homozygous are not viable without an intensive antenatal care. Here, we describe 4 patients diagnosed incidentally by cytogram appearance of the Advia® 2120i (Siemens) representing hemoglobin concentration according to red blood mean cellular volume (GR/VCH).
- Subjects :
- Adult
Cytodiagnosis methods
Cytodiagnosis standards
Elliptocytosis, Hereditary blood
Elliptocytosis, Hereditary pathology
Erythrocyte Indices
Female
Hematologic Tests
Humans
Male
Middle Aged
Pregnancy
Pregnancy Complications, Hematologic blood
Pregnancy Complications, Hematologic diagnosis
Pregnancy Complications, Hematologic pathology
Young Adult
Blood Cells pathology
Elliptocytosis, Hereditary diagnosis
Incidental Findings
Subjects
Details
- Language :
- English
- ISSN :
- 1950-6112
- Volume :
- 75
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Annales de biologie clinique
- Publication Type :
- Academic Journal
- Accession number :
- 29043981
- Full Text :
- https://doi.org/10.1684/abc.2017.1291