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Human umbilical cord mesenchymal stem cells increase interleukin-9 production of CD4 + T cells.
- Source :
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Experimental and therapeutic medicine [Exp Ther Med] 2017 Oct; Vol. 14 (4), pp. 3541-3548. Date of Electronic Publication: 2017 Aug 17. - Publication Year :
- 2017
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Abstract
- Mesenchymal stem cells (MSC) are able to differentiate into cells of multiple lineage, and additionally act to modulate the immune response. Interleukin (IL)-9 is primarily produced by cluster of differentiation (CD)4 <superscript>+</superscript> T cells to regulate the immune response. The present study aimed to investigate the effect of human umbilical cord derived-MSC (UC-MSC) on IL-9 production of human CD4 <superscript>+</superscript> T cells. It was demonstrated that the addition of UC-MSC to the culture of CD4 <superscript>+</superscript> T cells significantly enhanced IL-9 production by CD4 <superscript>+</superscript> T cells. Transwell experiments suggested that UC-MSC promotion of IL-9 production by CD4 <superscript>+</superscript> T cells was dependent on cell-cell contact. Upregulated expression of CD106 was observed in UC-MSC co-cultured with CD4 <superscript>+</superscript> T cells, and the addition of a blocking antibody of CD106 significantly impaired the ability of UC-MSC to promote IL-9 production by CD4 <superscript>+</superscript> T cells. Therefore, the results of the present study demonstrated that UC-MSC promoted the generation of IL-9 producing cells, which may be mediated, in part by CD106. The findings may act to expand understanding and knowledge of the immune modulatory role of UC-MSC.
Details
- Language :
- English
- ISSN :
- 1792-0981
- Volume :
- 14
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Experimental and therapeutic medicine
- Publication Type :
- Academic Journal
- Accession number :
- 29042945
- Full Text :
- https://doi.org/10.3892/etm.2017.4952