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Modeling of the homoeo domain suggests similar structure to repressors.

Authors :
Tsonis PA
Carperos V
Siahaan T
Source :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 1988 Nov 30; Vol. 157 (1), pp. 100-5.
Publication Year :
1988

Abstract

The sequences of the homoeo domain containing the three alpha-helices were modeled based on secondary structure prediction, sequence homologies and coordinates of known helix-turn-helix motif containing DNA-binding proteins. The model reveals very similar three dimensional structure to repressors and suggest binding to DNA with its helix 3.

Subjects

Subjects :
Amino Acid Sequence
Computer Simulation
Hydrogen Bonding
Models, Molecular
Molecular Sequence Data
Protein Conformation
Repressor Proteins
Structure-Activity Relationship
DNA-Binding Proteins ultrastructure
Genes, Homeobox

Details

Language :
English
ISSN :
0006-291X
Volume :
157
Issue :
1
Database :
MEDLINE
Journal :
Biochemical and biophysical research communications
Publication Type :
Academic Journal
Accession number :
2904263
Full Text :
https://doi.org/10.1016/s0006-291x(88)80017-2
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