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Predictors of functional recovery in first-episode psychosis: A systematic review and meta-analysis of longitudinal studies.
- Source :
-
Clinical psychology review [Clin Psychol Rev] 2017 Dec; Vol. 58, pp. 59-75. Date of Electronic Publication: 2017 Oct 06. - Publication Year :
- 2017
-
Abstract
- Background: Three out of four first-episode psychosis (FEP) patients achieve clinical remission following treatment. Unfortunately, functional recovery lags behind symptomatic remission, and many individuals with FEP remain socially isolated with poor functional outcomes.<br />Aims: To systematically compile and analyse predictors of functional recovery in FEP.<br />Method: Systematic review and meta-analysis of peer-reviewed, longitudinal studies reporting predictors of functioning, with a minimum 12-month follow-up and at least 80% of participants diagnosed with FEP.<br />Results: Out of 2205 citations, 274 articles were retrieved for detailed evaluation resulting in 50 eligible studies (N=6669). Sociodemographic, clinical, physical and neuroimaging variables had little impact on long-term functioning. Conversely duration of untreated psychosis (DUP), most cognitive variables, and concurrent remission of positive and negative symptoms were independently related to functional recovery.<br />Conclusions: These findings strongly support the rationale for early intervention in FEP. Novel treatments targeting cognitive deficits may improve functional outcomes in FEP.<br /> (Copyright © 2017. Published by Elsevier Ltd.)
Details
- Language :
- English
- ISSN :
- 1873-7811
- Volume :
- 58
- Database :
- MEDLINE
- Journal :
- Clinical psychology review
- Publication Type :
- Academic Journal
- Accession number :
- 29042139
- Full Text :
- https://doi.org/10.1016/j.cpr.2017.09.007