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Effects of 1-year growth hormone replacement therapy on thyroid volume and function of the children and adolescents with idiopathic growth hormone deficiency.
- Source :
-
Journal of pediatric endocrinology & metabolism : JPEM [J Pediatr Endocrinol Metab] 2017 Oct 26; Vol. 30 (11), pp. 1187-1190. - Publication Year :
- 2017
-
Abstract
- Background: There are different opinions about the effects of growth hormone replacement therapy (GHRT) on thyroid function and volume. This study aimed to assess the effects of GHRT on thyroid volume and function in the children and adolescents with growth hormone (GH) deficiency.<br />Methods: A total of 29 patients diagnosed with GH deficiency were enrolled in the study. The control group consisted of 29 cases matched for age, gender and pubertal period with the patients. Thyroid function tests and insulin-like growth factor levels were measured, simultaneously thyroid volumes were assessed by ultrasonography at the initiation period and at the end of GHRT.<br />Results: Thyroid volumes of the patient group was -0.55±1.1 standard deviations (SDs) initially; whereas at the end of 1 year it was found to be -0.29±1.29 SDs and both SDs of thyroid volumes did not differ significantly. The SDs of thyroid volume of the control group was -0.85±1.03 SDs initially and -0.72±0.85 SDs at the end of 1 year; and they did not differ significantly. On the other hand, after GHRT of 1 year, thyroid stimulating hormone (TSH) and free thyroxine (T4) levels decreased.<br />Conclusions: It was observed that SDs of thyroid gland volumes did not change in GH deficient children and adolescents after GHRT.
- Subjects :
- Adolescent
Case-Control Studies
Child
Female
Follow-Up Studies
Human Growth Hormone deficiency
Humans
Male
Prognosis
Thyroid Function Tests
Thyroid Gland drug effects
Thyrotropin blood
Thyroxine blood
Time Factors
Dwarfism, Pituitary drug therapy
Hormone Replacement Therapy
Human Growth Hormone therapeutic use
Thyroid Gland physiology
Subjects
Details
- Language :
- English
- ISSN :
- 2191-0251
- Volume :
- 30
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Journal of pediatric endocrinology & metabolism : JPEM
- Publication Type :
- Academic Journal
- Accession number :
- 29040069
- Full Text :
- https://doi.org/10.1515/jpem-2017-0210