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Usefulness of positron emission tomography (PET)/contrast-enhanced computed tomography (CE-CT) in discriminating between malignant and benign intraductal papillary mucinous neoplasms (IPMNs).
- Source :
-
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] [Pancreatology] 2017 Nov - Dec; Vol. 17 (6), pp. 911-919. Date of Electronic Publication: 2017 Oct 03. - Publication Year :
- 2017
-
Abstract
- Background/objectives: We evaluated the usefulness of positron emission tomography (PET)/contrast-enhanced computed tomography (CE-CT) in discriminating between malignant and benign intraductal papillary mucinous neoplasms (IPMNs).<br />Methods: PET/CE-CT imaging was conducted on 29 IPMN lesions, which subsequently underwent surgery. Preoperative findings on PET/CE-CT imaging were compared with the histological findings of the resected specimens to determine the diagnostic accuracy of PET/CE-CT imaging for evaluation of the differential diagnosis between benign and malignant IPMNs.<br />Results: The final diagnoses of the 29 IPMN lesions were 9 benign and 20 malignant. Overall, 18 of the 20 malignant cases were positive for FDG uptake, while 7 of 9 benign cases were negative. The sensitivity, specificity, and diagnostic accuracy for benign/malignant differentiation using FDG uptake as a marker were 90.0%, 77.8%, and 86.2%, respectively. When guideline-based high-risk findings were used as markers, sensitivity, specificity, and diagnostic accuracy for mural nodules were 50.0%, 66.7%, and 55.2%, while they were 40.0%, 56%, and 48.3% for main duct dilatation, respectively.<br />Conclusions: FDG uptake on PET is a useful new marker for malignancy in benign/malignant differentiation. Because PET/CE-CT imaging is a noninvasive imaging modality that can evaluate FDG uptake in addition to the conventional high-risk findings, we believe it should be the first-line method for determining therapeutic approaches to IPMN.<br /> (Copyright © 2017 IAP and EPC. Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Adenocarcinoma, Mucinous pathology
Aged
Carcinoma, Pancreatic Ductal pathology
Carcinoma, Papillary pathology
Contrast Media administration & dosage
Diagnosis, Differential
Diatrizoate Meglumine administration & dosage
Female
Humans
Male
Middle Aged
Tomography, X-Ray Computed methods
Adenocarcinoma, Mucinous diagnostic imaging
Carcinoma, Pancreatic Ductal diagnostic imaging
Carcinoma, Papillary diagnostic imaging
Pancreatic Neoplasms diagnostic imaging
Positron-Emission Tomography methods
Subjects
Details
- Language :
- English
- ISSN :
- 1424-3911
- Volume :
- 17
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
- Publication Type :
- Academic Journal
- Accession number :
- 29033011
- Full Text :
- https://doi.org/10.1016/j.pan.2017.09.010