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Live Leishmania tarentolae secreting HNP1 as an immunotherapeutic tool against Leishmania infection in BALB/c mice.
- Source :
-
Immunotherapy [Immunotherapy] 2017 Oct; Vol. 9 (13), pp. 1089-1102. - Publication Year :
- 2017
-
Abstract
- Aim: Several disadvantages about chemotherapy for leishmaniasis has reinforced discovery of novel therapeutic agents especially immunotherapeutics. HNP1, as a member of the mammalian antimicrobial peptides family, is an attractive molecule due to its broad functional spectrum. Here, the in vivo potency of HNP1 in transgenic Leishmania tarentolae as an immunotherapy tool against Leishmania major-infected BALB/c mice was examined.<br />Methods & Results: 3 weeks after infection with L. major, the treatment effect of L. tarentolae-HNP1-EGFP was pursued. The results were promising in respect to parasite load control and Th1 immune response polarization compared with controls.<br />Conclusion: Immunotherapy by live L. tarentolae secreting HNP1 can elicit cellular immune response in a susceptible mouse model in order to control L. major infection.
- Subjects :
- Animals
Cell Differentiation
Cells, Cultured
Disease Models, Animal
Female
Humans
Leishmaniasis immunology
Mice
Mice, Inbred BALB C
Organisms, Genetically Modified
Parasite Load
Th1-Th2 Balance
Transgenes genetics
alpha-Defensins genetics
Anti-Infective Agents therapeutic use
Immunotherapy methods
Leishmania physiology
Leishmaniasis therapy
Th1 Cells immunology
alpha-Defensins therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1750-7448
- Volume :
- 9
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- Immunotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 29032739
- Full Text :
- https://doi.org/10.2217/imt-2017-0076