Back to Search
Start Over
Aqueous Extract of Gynura Bicolor Attenuated Hepatic Steatosis, Glycative, Oxidative, and Inflammatory Injury Induced by Chronic Ethanol Consumption in Mice.
- Source :
-
Journal of food science [J Food Sci] 2017 Nov; Vol. 82 (11), pp. 2746-2751. Date of Electronic Publication: 2017 Oct 12. - Publication Year :
- 2017
-
Abstract
- Gynura bicolor leaf aqueous extract (GAE) is rich in phytochemicals including phenolic acids, flavonoids, carotenoids, and anthocyanins. Effects of GAE upon hepatic injury in mice with chronic ethanol intake were examined. Lieber-DeCarli liquid diet with ethanol was used to induce hepatic lipid accumulation, oxidative, glycative, and inflammatory injury. GAE at 0.25% or 0.5% was added in feeds, and supplied to mice consumed Lieber-DeCarli liquid diet with ethanol for 6 wk. Blood and liver were collected for analyses. Results showed that ethanol increased plasma and hepatic triglyceride and cholesterol content, and affected plasma levels of insulin, adiponectin, leptin, and ghrelin. GAE at both doses decreased lipid accumulation, and at high dose improved hormones abnormality. Histological data revealed that GAE supplement mitigated hepatic lipid deposit. Ethanol increased plasma N <superscript>ε</superscript> -(carboxyethymethyl)-lysine and pentosidine levels. GAE at high doses lowered those glycative factors. Ethanol depleted glutathione content, increased CYP2E1 activity and reactive oxygen species production, and reduced the activity of glutathione peroxide, glutathione reductase and catalase in liver. GAE supplement at both doses reversed these alterations and attenuated hepatic oxidative stress. GAE supplement also at both doses decreased hepatic inflammatory cytokines release in ethanol treated mice. These findings support that leaves of G. bicolor is a functional food with liver protective activities against ethanol.<br /> (© 2017 Institute of Food Technologists®.)
- Subjects :
- Alcohol Drinking adverse effects
Animals
Carotenoids administration & dosage
Carotenoids analysis
Catalase metabolism
Cytochrome P-450 CYP2E1
Cytokines immunology
Fatty Liver genetics
Fatty Liver immunology
Fatty Liver metabolism
Flavonoids administration & dosage
Flavonoids analysis
Glutathione metabolism
Glycosylation
Humans
Insulin metabolism
Liver drug effects
Liver metabolism
Male
Mice
Mice, Inbred C57BL
Oxidative Stress drug effects
Plant Extracts analysis
Plant Leaves chemistry
Reactive Oxygen Species metabolism
Triglycerides metabolism
Asteraceae chemistry
Ethanol adverse effects
Fatty Liver drug therapy
Plant Extracts administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1750-3841
- Volume :
- 82
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Journal of food science
- Publication Type :
- Academic Journal
- Accession number :
- 29023845
- Full Text :
- https://doi.org/10.1111/1750-3841.13930