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Diversity-driven and facile 1,3-dipolar cycloaddition to access dispirooxindole-imidazolidine scaffolds.
- Source :
-
Organic & biomolecular chemistry [Org Biomol Chem] 2017 Oct 25; Vol. 15 (41), pp. 8705-8708. - Publication Year :
- 2017
-
Abstract
- A diversity-driven three-component 1,3-dipolar cycloaddition of isatins, amino acids and isatin-derived ketimines was developed to facilely assemble dispirooxindole-imidazolidine skeletons bearing vicinal quaternary carbon centers. This protocol features additive-free, minimal solvent usage (0.1 mL DMSO/0.2 mmol scale), wide substrate scope (34 examples), mild reaction conditions (room temperature) and high chemical yield (up to 99%).
Details
- Language :
- English
- ISSN :
- 1477-0539
- Volume :
- 15
- Issue :
- 41
- Database :
- MEDLINE
- Journal :
- Organic & biomolecular chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 29022628
- Full Text :
- https://doi.org/10.1039/c7ob02319g