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Autologous Cell Therapy for Vascular Regeneration: The Role of Proangiogenic Cells.
- Source :
-
Current medicinal chemistry [Curr Med Chem] 2018; Vol. 25 (35), pp. 4518-4534. - Publication Year :
- 2018
-
Abstract
- Background: Autologous cell therapy represents a novel treatment option for vascular regeneration in different disease conditions, with experimental and clinical studies indicating a therapeutic potential for proangiogenic cells (PCs), including endothelial progenitor cells, in the treatment of coronary and peripheral artery disease.<br />Objective: To provide a summary of the therapeutic potential of PCs administration or mobilization in peripheral artery disease, ischemic heart and cerebrovascular diseases, diabetic microvascular complications and inflammatory rheumatic diseases.<br />Methods: We undertook a search of bibliographic databases for peer-reviewed research literature on the role of PCs in vascular regeneration in preclinical and clinical models.<br />Results: Improvement of ischemic symptoms has been reported in different trials evaluating PCs for the treatment of critical limb ischemia. However, in this setting, contrasting results from meta-analyses question the long-term clinical efficacy of PC-based approaches. Preclinical studies and clinical trials support the safety and feasibility of PC therapy in the treatment of ischemic heart and cerebrovascular diseases, while evidence indicating a benefit on hard clinical outcomes is uncertain. Despite accumulating experimental results support a therapeutic role for PCs in diabetic retinopathy, results from randomized clinical trials are lacking. Whether PC therapy may limit premature atherosclerosis and reduce cardiovascular risk in inflammatory rheumatic diseases needs to be investigated.<br />Conclusion: Although the potential clinical applications of PCs are accumulating, there is also evidence of multiple limitations for autologous PC therapy. Thus, novel strategies aimed at improving PC viability and angiogenic function are warranted in order to improve the efficacy of cell therapy applications.<br /> (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.)
- Subjects :
- Blood Vessels physiology
Cardiovascular Diseases pathology
Cell- and Tissue-Based Therapy
Endothelial Progenitor Cells cytology
Endothelial Progenitor Cells metabolism
Humans
Myocardial Infarction pathology
Myocardial Infarction therapy
Myocardial Ischemia pathology
Myocardial Ischemia therapy
Peripheral Arterial Disease pathology
Peripheral Arterial Disease therapy
Regeneration
Transplantation, Autologous
Cardiovascular Diseases therapy
Endothelial Progenitor Cells transplantation
Subjects
Details
- Language :
- English
- ISSN :
- 1875-533X
- Volume :
- 25
- Issue :
- 35
- Database :
- MEDLINE
- Journal :
- Current medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 29022506
- Full Text :
- https://doi.org/10.2174/0929867324666171012111603