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Postantifungal effect of micafungin against Candida albicans, Candida dubliniensis and Candida africana in the presence and absence of serum.
- Source :
-
The new microbiologica [New Microbiol] 2017 Oct; Vol. 40 (4), pp. 286-288. Date of Electronic Publication: 2017 Oct 10. - Publication Year :
- 2017
-
Abstract
- We compared the micafungin killing rate and postantifungal effect (PAFE) at 4, 16 and 32 mg/L in RPMI- 1640 and in 50% serum against the C. albicans complex. In RPMI-1640 PAFEs were 1.5 - >19.4, 9.7 - >20.1 and 15.9 - >18.5 hours for C. albicans, C. africana and C. dubliniensis, respectively. In 50% serum PAFEs decreased sharply to 0-1.7 hours for all three species; killing rates were always negative. Short growth inhibition without killing in 50% serum suggests that micafungin PAFE has a limited role in the eradication of the C. albicans complex from the bloodstream.
Details
- Language :
- English
- ISSN :
- 1121-7138
- Volume :
- 40
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The new microbiologica
- Publication Type :
- Academic Journal
- Accession number :
- 28994449