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Postantifungal effect of micafungin against Candida albicans, Candida dubliniensis and Candida africana in the presence and absence of serum.

Authors :
Kardos T
Saleh Q
Kovács R
Gesztelyi R
Kardos G
Bozó A
Tóth Z
Majoros L
Source :
The new microbiologica [New Microbiol] 2017 Oct; Vol. 40 (4), pp. 286-288. Date of Electronic Publication: 2017 Oct 10.
Publication Year :
2017

Abstract

We compared the micafungin killing rate and postantifungal effect (PAFE) at 4, 16 and 32 mg/L in RPMI- 1640 and in 50% serum against the C. albicans complex. In RPMI-1640 PAFEs were 1.5 - >19.4, 9.7 - >20.1 and 15.9 - >18.5 hours for C. albicans, C. africana and C. dubliniensis, respectively. In 50% serum PAFEs decreased sharply to 0-1.7 hours for all three species; killing rates were always negative. Short growth inhibition without killing in 50% serum suggests that micafungin PAFE has a limited role in the eradication of the C. albicans complex from the bloodstream.

Details

Language :
English
ISSN :
1121-7138
Volume :
40
Issue :
4
Database :
MEDLINE
Journal :
The new microbiologica
Publication Type :
Academic Journal
Accession number :
28994449