Back to Search
Start Over
The negative impact of HBV/HCV coinfection on cirrhosis and its consequences.
- Source :
-
Alimentary pharmacology & therapeutics [Aliment Pharmacol Ther] 2017 Dec; Vol. 46 (11-12), pp. 1054-1060. Date of Electronic Publication: 2017 Oct 09. - Publication Year :
- 2017
-
Abstract
- Background: Hepatitis B virus (HBV)/hepatitis C virus (HCV) confection has been rarely studied in nonasian series.<br />Aim: To compare the characteristics of HBV/HCV coinfected patients to those of HBV- or HCV-monoinfected patients in the ANRS CO22 HEPATHER cohort study.<br />Patients and Methods: Of the 20 936 included patients, 95 had HBV/HCV coinfection (hepatitis B surface antigen, anti-HCV antibody and HCV RNA positive) and were matched with 375 HBV- and 380 HCV-monoinfected patients on age, gender and time since HBV or HCV diagnosis.<br />Results: F3-F4 fibrosis was more frequent in coinfected patients (58%) than in HBV- (32%, P < .0001), but similar in HCV-monoinfected patients (52%, P = .3142). Decompensated cirrhosis was more frequent in coinfected patients (11%) than in HBV- (2%, P = .0002) or HCV- (4%, P = .0275) monoinfected patients. Past excessive alcohol use was more frequent in coinfected patients (26%) than in HBV (12%, P = .0011), but similar in HCV monoinfected patients (32%, P = .2868). Coinfected patients had a higher proportion with arterial hypertension (42%) than HBV- (26%) or HCV-monoinfected patients (25%) (P < .003). Multivariable analysis confirmed the association between F3-F4 fibrosis and HCV infection in HBV-infected patients (OR = 3.84, 95% CI 1.99-7.43) and the association between decompensated cirrhosis and coinfection in HBV infected (OR = 5.58, 95% CI 1.42-22.0) or HCV infected patients (OR = 3.02, 95% CI 1.22-7.44).<br />Conclusions: HCV coinfection harmfully affects liver fibrosis in HBV patients, while decompensated cirrhosis is increased in coinfected patients compared with HBV- or HCV-monoinfected patients. HCV treatment is as safe and effective in coinfected as monoinfected patients and should be considered following the same rules as HCV monoinfected patients.<br /> (© 2017 John Wiley & Sons Ltd.)
Details
- Language :
- English
- ISSN :
- 1365-2036
- Volume :
- 46
- Issue :
- 11-12
- Database :
- MEDLINE
- Journal :
- Alimentary pharmacology & therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 28994127
- Full Text :
- https://doi.org/10.1111/apt.14352