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Flaxseed Oil Alleviates Chronic HFD-Induced Insulin Resistance through Remodeling Lipid Homeostasis in Obese Adipose Tissue.
- Source :
-
Journal of agricultural and food chemistry [J Agric Food Chem] 2017 Nov 08; Vol. 65 (44), pp. 9635-9646. Date of Electronic Publication: 2017 Oct 25. - Publication Year :
- 2017
-
Abstract
- Emerging evidence suggests that higher circulating long-chain n-3 polyunsaturated fatty acids (n-3PUFA) levels were intimately associated with lower prevalence of obesity and insulin resistance. However, the understanding of bioactivity and potential mechanism of α-linolenic acid-rich flaxseed oil (ALA-FO) against insulin resistance was still limited. This study evaluated the effect of FO on high-fat diet (HFD)-induced insulin resistance in C57BL/6J mice focused on adipose tissue lipolysis. Mice after HFD feeding for 16 weeks (60% fat-derived calories) exhibited systemic insulin resistance, which was greatly attenuated by medium dose of FO (M-FO), paralleling with differential accumulation of ALA and its n-3 derivatives across serum lipid fractions. Moreover, M-FO was sufficient to effectively block the metabolic activation of adipose tissue macrophages (ATMs), thereby improving adipose tissue insulin signaling. Importantly, suppression of hypoxia-inducible factors HIF-1α and HIF-2α were involved in FO-mediated modulation of adipose tissue lipolysis, accompanied by specific reconstitution of n-3PUFA within adipose tissue lipid fractions.
- Subjects :
- Animals
Humans
Insulin metabolism
Lipid Metabolism
Lipids blood
Macrophages metabolism
Mice
Mice, Inbred C57BL
Obesity genetics
Obesity metabolism
Transcription Factors genetics
Transcription Factors metabolism
Adipose Tissue metabolism
Diet, High-Fat adverse effects
Insulin Resistance
Linseed Oil metabolism
Obesity diet therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1520-5118
- Volume :
- 65
- Issue :
- 44
- Database :
- MEDLINE
- Journal :
- Journal of agricultural and food chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 28988484
- Full Text :
- https://doi.org/10.1021/acs.jafc.7b03325