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Neurotoxicology and drug-related disorders.
- Source :
-
Handbook of clinical neurology [Handb Clin Neurol] 2017; Vol. 145, pp. 181-192. - Publication Year :
- 2017
-
Abstract
- Neuropsychiatric disorders caused by toxic substances pose a great diagnostic challenge due to the large variety of changes caused in the central and peripheral nervous system. The pathogenetic mechanisms at work are multifaceted and partly not solved. In human drug abusers (cannabis, opiates, cocaine, amphetamines, methamphetamine and "designer drugs"), a broad spectrum of central nervous system alterations are observed including infarction, intracerebral and subarachnoidal hemorrhage, hypoxic-ischemic leukoencephalopathy, infections, neuronal loss, specific astroglial and microglial reaction patterns, and vascular changes, including the endothelial cell as well as the basal lamina.<br /> (Copyright © 2017 Elsevier B.V. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 0072-9752
- Volume :
- 145
- Database :
- MEDLINE
- Journal :
- Handbook of clinical neurology
- Publication Type :
- Academic Journal
- Accession number :
- 28987169
- Full Text :
- https://doi.org/10.1016/B978-0-12-802395-2.00014-6