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Pig models on intestinal development and therapeutics.
- Source :
-
Amino acids [Amino Acids] 2017 Dec; Vol. 49 (12), pp. 2099-2106. Date of Electronic Publication: 2017 Oct 06. - Publication Year :
- 2017
-
Abstract
- The gastrointestinal tract plays a vital role in nutrient supply, digestion, and absorption, and has a crucial impact on the entire organism. Much attention is being paid to utilize animal models to study the pathogenesis of gastrointestinal diseases in response to intestinal development and health. The piglet has a body size similar to that of the human and is an omnivorous animal with comparable anatomy, nutritional requirements, and digestive and associated inflammatory processes, and displays similarities to the human intestinal microbial ecosystem, which make piglets more appropriate as an animal model for human than other non-primate animals. Therefore, the objective of this review is to summarize key attributes of the piglet model with which to study human intestinal development and intestinal health through probing into the etiology of several gastrointestinal diseases, thus providing a theoretical and hopefully practical, basis for further studies on mammalian nutrition, health, and disease, and therapeutics. Given the comparable nutritional requirements and strikingly similar brain developmental patterns between young piglets and humans, the piglet has been used as an important translational model for studying neurodevelopmental outcomes influenced by pediatric nutrition. Because of similarities in anatomy and physiology between pigs and mankind, more emphasises are put on how to use the piglet model for human organ transplantation research.
- Subjects :
- Animals
Animals, Newborn anatomy & histology
Animals, Newborn growth & development
Animals, Newborn physiology
Gastrointestinal Diseases physiopathology
Gastrointestinal Microbiome
Gastrointestinal Tract embryology
Gastrointestinal Tract growth & development
Gastrointestinal Tract microbiology
Humans
Neurodevelopmental Disorders therapy
Animal Nutritional Physiological Phenomena
Gastrointestinal Diseases therapy
Gastrointestinal Tract physiology
Models, Animal
Sus scrofa
Subjects
Details
- Language :
- English
- ISSN :
- 1438-2199
- Volume :
- 49
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Amino acids
- Publication Type :
- Academic Journal
- Accession number :
- 28986749
- Full Text :
- https://doi.org/10.1007/s00726-017-2497-z