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Age- and sex-related effects in children with mild traumatic brain injury on diffusion magnetic resonance imaging properties: A comparison of voxelwise and tractography methods.
- Source :
-
Journal of neuroscience research [J Neurosci Res] 2018 Apr; Vol. 96 (4), pp. 626-641. Date of Electronic Publication: 2017 Oct 06. - Publication Year :
- 2018
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Abstract
- Although there are several techniques to analyze diffusion-weighted imaging, any technique must be sufficiently sensitive to detect clinical abnormalities. This is especially critical in disorders like mild traumatic brain injury (mTBI), where pathology is likely to be subtle. mTBI represents a major public health concern, especially for youth under 15 years of age. However, the developmental period from birth to 18 years is also a time of tremendous brain changes. Therefore, it is important to establish the degree of age- and sex-related differences. Participants were children aged 8-15 years with mTBI or mild orthopedic injuries. Imaging was obtained within 10 days of injury. We performed tract-based spatial statistics (TBSS), deterministic tractography using Automated Fiber Quantification (AFQ), and probabilistic tractography using TRACULA (TRActs Constrained by UnderLying Anatomy) to evaluate whether any method provided improved sensitivity at identifying group, developmental, and/or sex-related differences. Although there were no group differences from any of the three analyses, many of the tracts, but not all, revealed increases of fractional anisotropy and decreases of axial, radial, and mean diffusivity with age. TBSS analyses resulted in age-related changes across all white matter tracts. AFQ and TRACULA revealed age-related changes within the corpus callosum, cingulum cingulate, corticospinal tract, inferior and superior longitudinal fasciculus, and uncinate fasciculus. The results are in many ways consistent across all three methods. However, results from the tractography methods provided improved sensitivity and better tract-specific results for identifying developmental and sex-related differences within the brain.<br /> (© 2017 Wiley Periodicals, Inc.)
- Subjects :
- Adolescent
Anisotropy
Brain anatomy & histology
Brain pathology
Brain Injuries, Traumatic pathology
Child
Corpus Callosum diagnostic imaging
Corpus Callosum pathology
Diffusion Magnetic Resonance Imaging methods
Female
Humans
Male
Pyramidal Tracts diagnostic imaging
Pyramidal Tracts pathology
Brain Injuries, Traumatic diagnostic imaging
Diffusion Tensor Imaging methods
Subjects
Details
- Language :
- English
- ISSN :
- 1097-4547
- Volume :
- 96
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of neuroscience research
- Publication Type :
- Academic Journal
- Accession number :
- 28984377
- Full Text :
- https://doi.org/10.1002/jnr.24142