Back to Search
Start Over
Adenosine receptors differentially regulate type 2 cytokine production by IL-33-activated bone marrow cells, ILC2s, and macrophages.
- Source :
-
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2018 Feb; Vol. 32 (2), pp. 829-837. Date of Electronic Publication: 2018 Jan 04. - Publication Year :
- 2018
-
Abstract
- Group 2 innate lymphoid cells (ILC2s) represent a rapid source of type 2 cytokines, such as IL-5 and IL-13, and play an important role in orchestrating type 2 immune response. Adenosine is an endogenous purine nucleoside, a catabolite of ATP that binds and activates ≥1 of 4 transmembrane G protein-coupled cell-surface adenosine receptors (ARs)-A <subscript>1</subscript> , A <subscript>2A</subscript> , A <subscript>2B</subscript> , and A <subscript>3</subscript> . Here, we studied the role of ARs in the regulation of cytokine production by ILC2s. We found that A <subscript>2B</subscript> ARs suppress the production of both IL-5 and IL-13 by ILC2s, whereas A <subscript>2A</subscript> ARs augment IL-5 production and fail to affect IL-13 release. Combined stimulation of all ARs led to the suppression of both IL-5 and IL-13 production, which indicated that A <subscript>2B</subscript> ARs dominate A <subscript>2A</subscript> ARs. Both pre- and post-transcriptional processes may be involved in the AR modulation of ILC2 IL-5 and IL-13 production. Thus, we identify adenosine as a novel negative regulator of ILC2 activation.-Csóka, B., Németh, Z. H., Duerr, C. U., Fritz, J. H., Pacher, P., Haskó, G. Adenosine receptors differentially regulate type 2 cytokine production by IL-33-activated bone marrow cells, ILC2s, and macrophages.
- Subjects :
- Animals
Bone Marrow Cells cytology
Interleukin-13 genetics
Interleukin-33 immunology
Interleukin-5 genetics
Lymphocyte Activation drug effects
Lymphocyte Activation genetics
Macrophage Activation drug effects
Macrophage Activation genetics
Macrophages cytology
Mice
Mice, Knockout
Receptor, Adenosine A2A genetics
Receptor, Adenosine A2B genetics
Th2 Cells cytology
Bone Marrow Cells immunology
Interleukin-13 immunology
Interleukin-33 pharmacology
Interleukin-5 immunology
Macrophages immunology
Receptor, Adenosine A2A immunology
Receptor, Adenosine A2B immunology
Th2 Cells immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1530-6860
- Volume :
- 32
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- FASEB journal : official publication of the Federation of American Societies for Experimental Biology
- Publication Type :
- Academic Journal
- Accession number :
- 28982732
- Full Text :
- https://doi.org/10.1096/fj.201700770R