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Telomere length, ATM mutation status and cancer risk in Ataxia-Telangiectasia families.
- Source :
-
Carcinogenesis [Carcinogenesis] 2017 Oct 01; Vol. 38 (10), pp. 994-1003. - Publication Year :
- 2017
-
Abstract
- Recent studies have linked constitutive telomere length (TL) to aging-related diseases including cancer at different sites. ATM participates in the signaling of telomere erosion, and inherited mutations in ATM have been associated with increased risk of cancer, particularly breast cancer. The goal of this study was to investigate whether carriage of an ATM mutation and TL interplay to modify cancer risk in ataxia-telangiectasia (A-T) families.The study population consisted of 284 heterozygous ATM mutation carriers (HetAT) and 174 non-carriers (non-HetAT) from 103 A-T families. Forty-eight HetAT and 14 non-HetAT individuals had cancer, among them 25 HetAT and 6 non-HetAT were diagnosed after blood sample collection. We measured mean TL using a quantitative PCR assay and genotyped seven single-nucleotide polymorphisms (SNPs) recurrently associated with TL in large population-based studies.HetAT individuals were at increased risk of cancer (OR = 2.3, 95%CI = 1.2-4.4, P = 0.01), and particularly of breast cancer for women (OR = 2.9, 95%CI = 1.2-7.1, P = 0.02), in comparison to their non-HetAT relatives. HetAT individuals had longer telomeres than non-HetAT individuals (P = 0.0008) but TL was not associated with cancer risk, and no significant interaction was observed between ATM mutation status and TL. Furthermore, rs9257445 (ZNF311) was associated with TL in HetAT subjects and rs6060627 (BCL2L1) modified cancer risk in HetAT and non-HetAT women.Our findings suggest that carriage of an ATM mutation impacts on the age-related TL shortening and that TL per se is not related to cancer risk in ATM carriers. TL measurement alone is not a good marker for predicting cancer risk in A-T families.<br /> (© The Author 2017. Published by Oxford University Press.)
- Subjects :
- Ataxia Telangiectasia genetics
Breast Neoplasms genetics
Female
Genetic Predisposition to Disease
Heterozygote
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide
Telomere Shortening genetics
bcl-X Protein genetics
Ataxia Telangiectasia complications
Ataxia Telangiectasia Mutated Proteins genetics
Mutation
Neoplasms genetics
Telomere genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1460-2180
- Volume :
- 38
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Carcinogenesis
- Publication Type :
- Academic Journal
- Accession number :
- 28981872
- Full Text :
- https://doi.org/10.1093/carcin/bgx074