11C-Choline-Pet Guided Stereotactic Body Radiation Therapy for Lymph Node Metastases in Oligometastatic Prostate Cancer.

Authors :: Franzese C
Lopci E
Di Brina L
D'Agostino GR
Navarria P
Mancosu P
Tomatis S
Chiti A
Scorsetti M
Source :: Cancer investigation [Cancer Invest] 2017 Oct 21; Vol. 35 (9), pp. 586-593. Date of Electronic Publication: 2017 Oct 05.
Publication Year :: 2017
Abstract: Introduction: aim is outcome of 11C-Choline-PET guided SBRT on lymph node metastases.<br />Materials and Methods: patients with 1 - 4 lymph node metastases detected by 11C-choline-PET were treated with SBRT. Toxicity, treated metastases control and Progression Free Survival were computed.<br />Results: twenty-six patients, 38 lymph node metastases were irradiated. No grade ≥ 2 toxicity. Median PSA-nadir after RT was 1.02 ng/mL. Post-treatment 11C-Choline-PET showed metabolic complete response in 17 metastases (44,7%), partial response in 9 metastases (38%).<br />Conclusion: SBRT is effective and safe for lymph node metastases. PET is important in identification of gross tumor and evaluation of the response.

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