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Specific depressive symptoms predict remission to aripiprazole augmentation in late-life treatment resistant depression.
- Source :
-
International journal of geriatric psychiatry [Int J Geriatr Psychiatry] 2018 Feb; Vol. 33 (2), pp. e330-e335. Date of Electronic Publication: 2017 Oct 03. - Publication Year :
- 2018
-
Abstract
- Objective: To identify which specific depressive symptoms predict remission to aripiprazole augmentation in late-life treatment resistant depression.<br />Methods: This is a secondary analysis of data from a late-life treatment resistant depression trial examining the safety and efficacy of aripiprazole augmentation. Participants aged 60 and above were randomized to aripiprazole augmentation (N = 91) versus placebo (N = 90). The main outcome was depression remission. Clinical predictors included individual Montgomery-Asberg Depression Rating Scale (MADRS) item scores categorized as symptomatic (scores >2) or nonsymptomatic (scores ≤2).<br />Results: Three MADRS items predicted depression remission with aripiprazole augmentation: symptomatic scores on sleep disturbance and nonsymptomatic scores on apparent sadness and inability to feel. The 2-way and 3-way interaction terms of these MADRS items were not significant predictors of remission; therefore, the models' ability to predict remission was not improved by combining the significant MADRS items.<br />Conclusions: The identification of specific depressive symptoms, which can be clinically assessed, can be used to inform treatment decisions. Older adults with treatment resistant depression that present with sleep disturbances, lack of apparent sadness, or lack of inability to feel should be considered for aripiprazole augmentation.<br /> (Copyright © 2017 John Wiley & Sons, Ltd.)
- Subjects :
- Aged
Depressive Disorder, Major psychology
Depressive Disorder, Treatment-Resistant psychology
Female
Humans
Male
Middle Aged
Psychiatric Status Rating Scales
Antidepressive Agents therapeutic use
Aripiprazole therapeutic use
Depressive Disorder, Major drug therapy
Depressive Disorder, Treatment-Resistant drug therapy
Serotonin 5-HT1 Receptor Agonists therapeutic use
Serotonin 5-HT2 Receptor Antagonists therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1099-1166
- Volume :
- 33
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- International journal of geriatric psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 28975710
- Full Text :
- https://doi.org/10.1002/gps.4813