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Proinflammatory Cytokine Responses in Extra-Respiratory Tissues During Severe Influenza.

Authors :
Short KR
Veeris R
Leijten LM
van den Brand JM
Jong VL
Stittelaar K
Osterhaus ADME
Andeweg A
van Riel D
Source :
The Journal of infectious diseases [J Infect Dis] 2017 Oct 17; Vol. 216 (7), pp. 829-833.
Publication Year :
2017

Abstract

Severe influenza is often associated with disease manifestations outside the respiratory tract. While proinflammatory cytokines can be detected in the lungs and blood of infected patients, the role of extra-respiratory organs in the production of proinflammatory cytokines is unknown. Here, we show that both 2009 pandemic H1N1 influenza A (H1N1) virus and highly pathogenic avian influenza A (H5N1) virus induce expression of tumor necrosis factor α, interleukin-6, and interleukin-8 in the respiratory tract and central nervous system. In addition, H5N1 virus induced cytokines in the heart, pancreas, spleen, liver, and jejunum. Together, these data suggest that extra-respiratory tissues contribute to systemic cytokine responses, which may increase the severity of influenza.<br /> (© The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.)

Details

Language :
English
ISSN :
1537-6613
Volume :
216
Issue :
7
Database :
MEDLINE
Journal :
The Journal of infectious diseases
Publication Type :
Academic Journal
Accession number :
28973159
Full Text :
https://doi.org/10.1093/infdis/jix281