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Natural polyreactive IgA antibodies coat the intestinal microbiota.
- Source :
-
Science (New York, N.Y.) [Science] 2017 Oct 20; Vol. 358 (6361). Date of Electronic Publication: 2017 Sep 28. - Publication Year :
- 2017
-
Abstract
- Large quantities of immunoglobulin A (IgA) are constitutively secreted by intestinal plasma cells to coat and contain the commensal microbiota, yet the specificity of these antibodies remains elusive. Here we profiled the reactivities of single murine IgA plasma cells by cloning and characterizing large numbers of monoclonal antibodies. IgAs were not specific to individual bacterial taxa but rather polyreactive, with broad reactivity to a diverse, but defined, subset of microbiota. These antibodies arose at low frequencies among naïve B cells and were selected into the IgA repertoire upon recirculation in Peyer's patches. This selection process occurred independent of microbiota or dietary antigens. Furthermore, although some IgAs acquired somatic mutations, these did not substantially influence their reactivity. These findings reveal an endogenous mechanism driving homeostatic production of polyreactive IgAs with innate specificity to microbiota.<br /> (Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.)
- Subjects :
- Animals
Antibodies, Monoclonal genetics
Antibodies, Monoclonal immunology
Antigens immunology
B-Lymphocytes immunology
Bacteria immunology
Germ-Free Life immunology
Immunoglobulin A genetics
Intestinal Mucosa immunology
Intestinal Mucosa microbiology
Mice
Mice, Inbred C57BL
Peyer's Patches immunology
Symbiosis
Gastrointestinal Microbiome immunology
Immunoglobulin A immunology
Plasma Cells immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1095-9203
- Volume :
- 358
- Issue :
- 6361
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 28971969
- Full Text :
- https://doi.org/10.1126/science.aan6619