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Role of Alanine Racemase Mutations in Mycobacterium tuberculosis d-Cycloserine Resistance.
- Source :
-
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2017 Nov 22; Vol. 61 (12). Date of Electronic Publication: 2017 Nov 22 (Print Publication: 2017). - Publication Year :
- 2017
-
Abstract
- A screening of more than 1,500 drug-resistant strains of Mycobacterium tuberculosis revealed evolutionary patterns characteristic of positive selection for three alanine racemase (Alr) mutations. We investigated these mutations using molecular modeling, in vitro MIC testing, as well as direct measurements of enzymatic activity, which demonstrated that these mutations likely confer resistance to d-cycloserine.<br /> (Copyright © 2017 Nakatani et al.)
- Subjects :
- Alanine Racemase metabolism
Antibiotics, Antitubercular pharmacology
Bacterial Proteins metabolism
Evolution, Molecular
Gene Expression
Microbial Sensitivity Tests
Mycobacterium tuberculosis classification
Mycobacterium tuberculosis drug effects
Mycobacterium tuberculosis enzymology
Phylogeny
Selection, Genetic
Alanine Racemase genetics
Bacterial Proteins genetics
Cycloserine pharmacology
Drug Resistance, Bacterial genetics
Mutation
Mycobacterium tuberculosis genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1098-6596
- Volume :
- 61
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Antimicrobial agents and chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 28971867
- Full Text :
- https://doi.org/10.1128/AAC.01575-17